Studies on Positive Inotropic Agents. IV. : Synthesis of 5-(3-Amino-2-hydroxypropoxy)-3,4-dihydro-8-hydroxy-2(1H)-quinolinone Derivatives(Medeicinal Chemistry,Chemical)

スポンサーリンク

概要

• 論文の詳細を見る

• Many 5-(3-amino-2-hydroxypropoxy)-3,4-dihydro-8-hydroxy-2(1H)-quinoIinone derivatives were synthesized and examined for positive inotropic activity on the canine heart. These compounds were prepared by the reaction of 8-alkoxy-5-(2,3-epoxypropoxy)-2(1H)-quinolinone derivatives and various amines. Among them, 3,4-dihydro-8-hydroxy-5-[3-(1,1,3,3-tetramethylbutylamino)propoxy]-2(1H)-quinolinone hydrochloride (IIIf) was found to have potent positive inotropic activity with a relatively minor increase in heart rate.

• 公益社団法人日本薬学会の論文
• 1987-09-25

著者

• Yamamura Y

  First Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.

• TOMINAGA Mineko

  Department of Biophysics, Universidade Federal de Sao Paulo

• Nakagawa Kazuyuki

  Second Institute Of New Drug Reserch Otsuka Pharmaceutical Co. Ltd.

• Tominaga M

  Department Of Biophysics Universidade Federal De Sao Paulo

• YAMASHITA Shuji

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• Yabuuchi Y

  First Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.

• Yabuuchi Youichi

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• Ogawa H

  Second Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.

• TOMINAGA MICHIAKI

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• OGAWA HIDENORI

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• YO EIYU

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• NAKAGAWA KAZUYUKI

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• Yo E

  Otsuka Pharmaceutical Co. Ltd. Tokushima Jpn

• Yamashita Shuji

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

関連論文

• Antidiuretic Effects of a Novel Nonpeptide Vasopressin V_2-Receptor Agonist, OPC-51803, Administered Orally to Dogs
• Effects of OPC-51803, a Novel, Nonpeptide Vasopressin V_2-Receptor Agonist, on Micturition Frequency in Brattleboro and Aged Rats
• OPC-21268 Antagonizes Arginine Vasopressin-Induced Vasoconstrictor Response in the Spinally-Anesthetized Dog
• Evaluation of the Trifluoromethanosulfonic Acid/Trifluoroacetic Acid/Thioanisole Cleavage Procedure for Application in Solid-Phase Peptide Synthesis
• Resin Selection Based on the Lability of Peptidyl-Resin Linkage towards HF and TFA Steps : Dependence on the C-Terminal Amino Acid and Peptide Length
• Cardiovascular Effects of the Combination of OPC - 18790 and Dopamine in Halothane - Anesthertized Dogs
• Fmoc-POAC : [(9-Fluorenylmethyloxycarbonyl)-2, 2, 5, 5-tetramethylpyrro-lidine-N-oxyl-3-amino-4-carboxylic Acid] : A Novel Protected Spin Labeled β-Amino Acid for Peptide and Protein Chemistry
• Preventive Effects of Dehydroepiandrosterone Acetate on the Fatty Liver Induced by Orotic Acid in Male Rats
• Preparation of Partially Protected Peptide Thioesters Containing a Cysteine Residue and Their Segment Condensation
• Synthesis and Biological Activities of Optically Active 6-[3-(3,4-Dimethoxybenzylamino)-2-hydroxypropoxy]-2(1H)-quinolinone (OPC-18790)
• Structure-Activity Relationships of Non-peptide Vasopressin V_ Antagonists : 1-(1-Multi-substituted Benzoyl 4-Piperidyl)-3,4-dihydro-2(1H)-quinolinones
• Studies on Positive Inotropic Agents. IV. : Synthesis of 5-(3-Amino-2-hydroxypropoxy)-3,4-dihydro-8-hydroxy-2(1H)-quinolinone Derivatives(Medeicinal Chemistry,Chemical)
• CARDIAC EFFECTS OF A NEW POSITIVE INOTROPIC AGENT, OPC-8212, UNDER INFLUENCE OF DIGITALIS : Heart Failure, Cardiotonic Drugs : FREE COMMUNICATIONS (V) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Prevention of Orotic-Acid-Induced Fatty Liver in Male Rats by Dehydroepiandrosterone and/or Phenobarbital.

もっと見る 閉じる

スポンサーリンク