Prevention of Orotic-Acid-Induced Fatty Liver in Male Rats by Dehydroepiandrosterone and/or Phenobarbital.

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概要

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• Dehydroepiandrosterone (DHEA) is a steroid hormone which induces the peroxisome proliferation in rodents. The fatty liver induced by orotic acid and a high sucrose diet in male rats was prevented by the administration of DHEA and/or phenobarbital (PB). A significant increase in the liver weight was induced in the DHEA group (relative weight) and the DHEA + PB group (absolute and relative weight). The liver weight increased more conspicuously in the DHEA + PB group than in the DHEA group. The increase in the liver weight was caused by an increase in the cell size and peroxisome number. In addition, the administration of DHEA alone and the combination of DHEA and PB prevented the lipid droplet accumulation in hepatocytes. The administration of PB alone also prevented the accumulation of lipid droplets without any increase in the liver weight.

• 公益社団法人 日本獣医学会の論文

著者

• Goto Hirohiko

  The United Graduate School Of Veterinary Science Yamaguchi University

• MAKITA Takashi

  The United Graduate School of Veterinary Science, Yamaguchi University

• Yamashita Shuji

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• Makita Takashi

  The United Graduate School Of Veterinary Science Yamaguchi University

関連論文

• Preventive Effects of Dehydroepiandrosterone Acetate on the Fatty Liver Induced by Orotic Acid in Male Rats
• Studies on Positive Inotropic Agents. IV. : Synthesis of 5-(3-Amino-2-hydroxypropoxy)-3,4-dihydro-8-hydroxy-2(1H)-quinolinone Derivatives(Medeicinal Chemistry,Chemical)
• Prevention of Orotic-Acid-Induced Fatty Liver in Male Rats by Dehydroepiandrosterone and/or Phenobarbital.

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