Preventive Effects of Dehydroepiandrosterone Acetate on the Fatty Liver Induced by Orotic Acid in Male Rats

スポンサーリンク

概要

• 論文の詳細を見る

• Preventive effects of dehydroepiandrosteone acetate (DHEA-A) and clofibrate (positive control substance) on the fatty liver induced by orotic acid (OA) were examined on the male Sprague-Dawley rats fed a high sucrose based diet containing 1% OA and this diet further mixed with 0.5% DHEA-A or 0.5% clofibrate for 2 weeks. Numerous lipid droplets were observed in the hepatocytes of the rats treated with OA alone, but not in those treated with DHEA-A or clofibrate. In comparison to the group with OA alone, the DHEA-A or clofibrate treated rats showed a larger relative liver weight (to body weight) which was accompanied by increased peroxisomes in the hepatocytes. These results indicate that DHEA-A, as well as clofibrate, may prevent OA-induced fatty liver.

• 社団法人　日本実験動物学会の論文
• 1998-10-01

著者

• Goto Hirohiko

  The United Graduate School Of Veterinary Science Yamaguchi University

• YAMASHITA Shuji

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• MAKITA Takashi

  The United Graduate School of Veterinary Science, Yamaguchi University

• Yamashita S

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• Yamashita Shuji

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• Makita Takashi

  The United Graduate School Of Veterinary Science Yamaguchi University

関連論文

• Preventive Effects of Dehydroepiandrosterone Acetate on the Fatty Liver Induced by Orotic Acid in Male Rats
• Studies on Positive Inotropic Agents. IV. : Synthesis of 5-(3-Amino-2-hydroxypropoxy)-3,4-dihydro-8-hydroxy-2(1H)-quinolinone Derivatives(Medeicinal Chemistry,Chemical)
• Prevention of Orotic-Acid-Induced Fatty Liver in Male Rats by Dehydroepiandrosterone and/or Phenobarbital.

スポンサーリンク