Synthesis and Biological Activities of Optically Active 6-[3-(3,4-Dimethoxybenzylamino)-2-hydroxypropoxy]-2(1H)-quinolinone (OPC-18790)
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概要
- 論文の詳細を見る
The enanitomers of 6-[3-(3,4-dimethoxybenzylamino)-2-hydroxypropoxy]-2(1H)-quinolinone (OPC-18790), a novel cardiotonic agent, were synthesized and evaluated for positive inotropic activity. The key intermediates, 2,3-epoxypropoxy derivatives, were obtained by the alkylation of 6-hydroxy-2(1H)-quinolinone with optically active epichlorohydrin and subsequent ring closure.
- 公益社団法人日本薬学会の論文
- 1996-08-15
著者
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Miura Tomisato
弘前大学 理工学研究科物質理工学
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MORI Toyoki
2nd Tokushima Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd.
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TOMINAGA Michiaki
2nd Tokushima Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd.
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YABUUCHI Youichi
2nd Tokushima Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd.
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Yamamura Y
First Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.
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Mori Tomonori
(present Address)faculty Of Engineering Towa University
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TOMINAGA Mineko
Department of Biophysics, Universidade Federal de Sao Paulo
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Mori T
First Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.
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Tominaga M
Department Of Biophysics Universidade Federal De Sao Paulo
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Mori Toyoki
2nd Tokushima Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.
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Tsujimi Sachiko
2nd Tokushima Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.
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Yabuuchi Y
First Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.
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FUJIOKA Takafumi
(Present address)Otsuka Pharmaceutical Co., Ltd.
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TERAMOTO Shuji
2nd Tokushima Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd.
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TAKEMOTO Kazumi
2nd Tokushima Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd.
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HOSOKAWA Tetsumi
2nd Tokushima Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd.
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SUMIDA Takumi
2nd Tokushima Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd.
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Sumida T
2nd Tokushima Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.
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Teramoto Shuji
2nd Tokushima Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.
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Hosokawa T
2nd Tokushima Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.
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Takemoto Kazumi
2nd Tokushima Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.
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Fujioka Takafumi
(present Address)otsuka Pharmaceutical Co. Ltd.
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