Characterization of Fe(III)-Deferoxamine and Mn(II)-Pectin as Magnetic Resonance Imaging Contrast Agents

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概要

• 論文の詳細を見る

• To find new contrast agents for magnetic resonance imaging (MRI), the spin-lattice relaxation time (T_1)-reducing activities of metal complexes of EDTA, N-hydroxyethyethylenediamine-N, N', N'-triacetic acid (HEDTA), diethylenetriamine-N, N, N', N", N‴-pentaacetic acid (DTPA), deferoxamine, mugineic acid, and pectin with Fe(III) or Mn(II) were investigated. Strong activity was found in Fe(III)-deferoxamine, Fe(III)-mugineic acid, or Mn(II)-pectin. In the actual MRI tomogram, Fe(III)-deferoxamine exhibited a contrast-enhancing effect comparable with that of Gd(III)-DTPA, and a much stronger effect was observed for Mn(II)-pectin. Fe(III)-deferoxamine and the Mn(II)-pectin appear to be candidates, respectively, as a new intravenous contrast agent and an oral gastrointestinal one.

• 公益社団法人日本薬学会の論文
• 1998-12-15

著者

• Ishii K

  Division Of Imaging Research Hyogo Institute For Aging Brain And Cognitive Disorders

• MINO Yoshiki

  Department of Neurosurgery, Toyama Medical and Pharmaceutical University

• SASAKI Masahiro

  Hyogo Institute for Aging Brain and Cognitive Disorders

• Mori Tetsuya

  Department Of Radiology And Nuclear Medicine Hyogo Brain And Heart Center

• Sasaki M

  Division Of Imaging Research Hyogo Institute For Aging Brain And Cognitive Disorders

• KITAGAKI Hajime

  Hyogo Institute for Aging Brain and Cognitive Disorders

• ISHII Kazunari

  Hyogo Institute for Aging Brain and Cognitive Disorders

• MORI Tetsuya

  Hyogo Institute for Aging Brain and Cognitive Disorders

• YAMADA Katsuki

  Sakai Chemical Industry Co., Ltd.,

• NAGASAWA Osamu

  Sakai Chemical Industry Co., Ltd.,

• Ishii Kazunari

  Division Of Imaging Research Hyogo Institute For Aging Brain And Cognitive Disorders

• Mori T

  First Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.

• Mino Y

  Osaka Univ. Pharmaceutical Sci. Osaka Jpn

• Yamada K

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Mino Yoshiki

  Department Of Environment Analysis Osaka University Of Pharmaceutical Sciences

• Nagasawa Osamu

  Sakai Chemical Industry Co. Ltd.

• Yamada Katsuya

  Graduate School Of Pharmaceutical Sciences Nagoya City University

• Sasaki Masahiro

  Division Of Laboratory Diagnosis Sapporo Medical University School Of Medicine

• Ishii Kazunari

  Hyogo Brain And Heart Center Hyogo Jpn

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