A Convenient Synthesis of Immunosuppressive Agent FTY720 Using the Petasis Reaction
スポンサーリンク
概要
- 論文の詳細を見る
A convenient synthesis of immunosuppressive agent FTY720 (1) using the Petasis reaction was developed. 4-Octylbenzaldehyde (9) was converted into 1-ethenyl-4-octylbenzene (11) by two-step synthesis. Hydroboration of 11 using catecholborane and hydrolysis gave (E)-2-(4-octylphenyl) vinylboronic acid (4). The Petasis reaction of 4, dihydroxyacetone (3), and benzylamine following catalytic hydrogenation afforded FTY720 (1).
- 公益社団法人日本薬学会の論文
- 2005-01-01
著者
-
IGUCHI Kazuhiro
Department of Pharmaceutics, Gifu Pharmaceutical University
-
Ishii K
Division Of Imaging Research Hyogo Institute For Aging Brain And Cognitive Disorders
-
Ishihara Kazuhiko
Department Of Regulation Biochemistry Kitasato University Graduate School Of Medical Sciences
-
Ishii Kazunari
Division Of Imaging Research Hyogo Institute For Aging Brain And Cognitive Disorders
-
Arai Satoshi
Meiji Pharmaceutical University
-
SUGIYAMA Shigeo
Meiji Pharmaceutical University
-
KIRIYAMA Matsuri
Meiji Pharmaceutical University
-
ISHII Keitaro
Meiji Pharmaceutical University
-
Ishii Keitaro
Meiji College Of Pharmacy
-
Sugiyama S
Meiji Pharmaceutical University
-
Ishii Kazunari
Kinki Univ. School Of Medicine Osaka Jpn
関連論文
- Separation and Identification of Urinary Proteins Following Digital Rectal Examination in Patients with Benign Prostatic Hypertrophy
- Reaction of 1-Alkyl-3,4-dihydroisoquinolines with 4-Nitrobenzoyl Cyanide and Diketene
- Reaction of N-(1-Phenylalkylidene)benzylamines with Benzoyl Cyanides
- Activation of Caspase-3, Proteolytic Cleavage of DFF and No Oligonucleosomal DNA Fragmentation in Apoptotic Molt-4 Cells
- Zinc Induces Mixed Types of Cell Death, Necrosis, and Apoptosis, in Molt-4 Cells.
- Zinc Induces Mixed Types of Cell Death, Necrosis, and Apoptosis, in Molt-4 Cells^1
- Decreased Thymosinβ_4 in Apoptosis Induced by a Variety of Antitumor Drugs.
- Induction of Necrosis by Zinc in Prostate Carcinoma Cells and Identification of Proteins Increased in Association with This Induction.
- 希土類およびハフニウムトリフラートを用いたカルボカチオン生成と各種求核試薬との反応
- ペリ環状反応の化学とその複素環化合物合成への応用
- Photocyclization Reactions of Epoxy Nitriles via Carbonyl Ylides. Formation of Spiroketals, Spiroethers, and a Spirolactone
- Studies on Conjugated Nitriles. VI. Reaction of 2-Methylquinoline and Related Compounds with Acyl Cyanides
- 遠赤外線照射と運動による人の汗の研究 : ナトリウム, カリウムイオン及び乳酸の濃度
- Addition Reactions of Diketene. IV. Reaction of Diketene with Thioureas, Thioamide, and Aminothiol
- Aminopeptidase N Regulated by Zinc in Human Prostate Participates in Tumor Cell Invasion.
- Decreases of Metallothionein and Aminopeptidase N in Rental Cancer Tissues.
- Decreases of Metallothionein and Aminopeptidase N in Renal Cancer Tissues
- Cerebral perfusion pattern of idiopathic normal pressure hydrocephalus studied by SPECT and statistical brain mapping
- Regional cerebral blood flow and oxygen metabolism in a patient with Korsakoff syndrome
- Comparison of FDG-PET and IMP-SPECT in patients with dementia with Lewy bodies
- Usefulness of intravascular ultrasonography for treatment of a ruptured vertebral dissecting aneurysm
- Early disappearance of calcification in posterior paraspinal muscles in a patient with rhabdomyolysis associated with neuroleptic malignant syndrome
- Automatic volumetric measurement of segmented brain structures on magnetic resonance imaging
- Inhibition of Aminopeptidase N (AP-N) and Urokinase-Type Plasminogen Activator (uPA) by Zinc Suppresses the Invasion Activity in Human Urological Cancer Cells.
- Extract from Serenoa repens Suppresses the Invasion Activity of Human Urological Cancer Cells by Inhibiting Urokinase-Type Plasminogen Activator.
- Inhibition of Aminopeptidase N(AP-N)and Urokinase-Type Plasminogen Activator(uPA)by Zinc Suppresses the Invasion Activity in Human Urological Cancer Cells
- Extract from Serenoa repens Suppresses the Invasion Activity of Human Urological Cancer Cells by Inhibiting Urokinase-Type Plasminogen Activator
- Characterization of Rat Gastric Mucins Using a Monoclonal Antibody, RGM23, Recognizing Surface Mucous Cell-Type Mucins
- Rat Gastric Mucins Recognized by Monoclonal Antibodies RGM21 and HIK1083: Isolation of Mucin Species Characteristic of the Surface and Glandular Mucosa
- Buformin Suppresses the Expression of Glyceraldehyde 3-Phosphate Dehydrogenase(Biopharmacy)
- Regulators for Blood Glucose Level Affect Gene Expression of Aquaporin 3(Biopharmacy)
- Identification of Differentially Expressed Genes in Hepatic HepG2 Cells Treated with Acetaminophen Using Suppression Subtractive Hybridization(Biochemistry)
- Metabolite Profiles of Flutamide in Serum from Patients with Flutamide-Induced Hepatic Dysfunction(Biopharmacy)
- Myristoleic Acid, a Cytotoxic Component in the Extract from Serenoa repens, Induces Apoptosis and Necrosis in Human Prostatic LNCaP Cells.
- Variaion in FDG uptakes in different regions in normal human brain as a function of the time (30 and 60 mimutes) after injection o FDG
- Characterization of Fe(III)-Deferoxamine and Mn(II)-Pectin as Magnetic Resonance Imaging Contrast Agents
- Glucose metabolism evaluated by positron emission tomography in Lafora disease
- Cerebral blood flow changes in the primary motor and premotor cortices during hyperventilation
- Reaction of Various Lectins to Mucin Derived from the Different Layers of Rat Gastric Mucosa : Comparison of Enzyme-Linked Lectin Binding Assay with Lectin Histochemistry
- Rat Gastric Mucous Gel Layer Contains Sialomucin Not Produced by the Stomach
- Recovery of mucin content in surface layer of rat gastric mucosa after HCI-aspirin-induced mucosal damage
- Mucosal Protection by Shokyo, a Crude Drug, against Ethanol-induced Gastric Damage in Rat
- A Convenient Synthesis of Immunosuppressive Agent FTY720 Using the Petasis Reaction
- Stereoselective Gram-Scale Synthesis of (S)-5,5-Dimethyl-4-phenyloxazolidin-2-one
- In vitro and ex vivo blood compatibility study of 2-methacryloyloxyethyl phosphorylcholine (MPC) copolymer-coated hemodialysis hollow fibers
- Effects of indomethacin on the rat small intestinal mucosa : immunohistochemical and biochemical studies using anti-mucin monoclonal antibodies