Isolation and Structure of a Monomethylated Ganglioside Possessing Neuritogenic Activity from the Ovary of the Sea Urchin Diadema setosum
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概要
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A new monomethylated ganglioside, DSG-A (3), was obtained, together with four known gangliosides, compounds (1, 2, 4, 5), from the lipid fraction of the chloroform/methanol extract of the ovary of the sea urchin Diadema setosum. The structures of the new ganglioside was determined on the basis of chemical and spectroscopic evidence to be 1-O-[9-O-methyl-(N-acetyl-α-D-neuraminosyl)-(2→6)-β-D-glucopyranosyl]-ceramide (3). The ceramide moiety of 3 was composed of C_<18>-phytosphingosine base, and 2-hydroxy and nonhydroxylated fatty acid units. These gangliosides showed neuritogenic activity toward the rat pheochromocytoma cell line PC-12 in the presence of nerve growth factor, in which compound 3 showed the most potent activity.
- 公益社団法人日本薬学会の論文
- 2008-05-01
著者
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INAGAKI MASANORI
Faculty of Pharmaceutical Sciences, Kyushu University
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HIGUCHI RYUICHI
Faculty of Pharmaceutical Sciences, Kyushu University
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HIGUCHI Ryuichi
Graduate School of Pharmaceutical Sciences, Kyushu University
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YAMADA Koji
Faculty of Engineering, Saitama University
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Miyamoto Tomofumi
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
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INAGAKI Masanori
Graduate School of Pharmaceutical Sciences, Kyushu University
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Higuchi Ryuichi
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
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Higuchi Ryuichi
Faculty Of Pharmaceutical Sciences Kyushu University
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Kusumoto Toshihide
Faculty Of Pharmaceutical Sciences Kyushu University
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Yamada K
Graduate School Of Pharmaceutical Sciences Kyushu University
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TANABE Kaoru
Faculty of Pharmaceutical Sciences, Kyushu University
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MIYAMOTO Tomofumi
Faculty of Pharmaceutical Sciences, Kyushu University
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Miyamoto T
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
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Yamada Katsuya
Graduate School Of Pharmaceutical Sciences Nagoya City University
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Tanabe Kaoru
Faculty Of Pharmaceutical Sciences Kyushu University
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Inagaki Masanori
Faculty Of Pharmaceutical Sciences Kyushu University
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Yamada Kenji
Tokyo University Of Pharmacy And Life Sciences School Of Pharmacy
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Maruta Tomoki
Graduate School Of Pharmaceutical Sciences Kyushu University
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Ito Masaki
The First Department Of Internal Medicine Mie University School Of Medicine
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Inagaki M
Graduate School Of Pharmaceutical Sciences Chiba University
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Yamada Koji
Faculty Of Engineering Saitama University
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