Water-soluble Component in Dried Chrysanthemum Flower Stimulates Tumor Necrosis Factor-α Production by Mouse Macrophage-like Cell Line RAW264.7

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概要

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• To clarify immunoregulatory activity of “Shiranui Himekiku” (Chrysanthemum indicam×Erigeron annus), we examined the effect on tumor necrosis factor α (TNF-α) production by mouse macrophage-like cell line RAW264.7. The dried chrysanthemum flower (CF) petals were extracted with water, and the cells were cultured in the presence of the extract. CF extract significantly enhanced TNF-α production of the cells by the dose-dependent manner. Diluted CF solution did not significantly affect the cell number and viability ; however, non-diluted solution suppressed the cell proliferation and decreased the cell viability. Heating CF extract at 100°C for 30min enhanced the activity of water extract markedly, and freeze-thawing only moderately. The TNF-α production enhancing activity of the extract was observed within 3h. These results suggest that the TNF-α production enhancing activity of CF extract can be recovered efficiently by hot water extraction and preserved stably by freezing.

• 社団法人　日本食品科学工学会の論文
• 2006-05-01

著者

• Tachibana Hirofumi

  九州大学 農学部生物機能化学食糧化学

• YAMADA Koji

  Faculty of Engineering, Saitama University

• Yamashita Kenji

  Biochemical Research Laboratories Kanegafuchi Chemical Industry Co. Ltd.

• Tachibana Hirofumi

  Division Of Bioresources And Bioenvironmental Science Kyushu University

• Tachibana Hirofumi

  Faculty Of Agriculture Kyushu University

• Tachibana Hirofumi

  Department Of Food Science And Technology Faculty Of Agriculture Kyushu University

• Fujimura Yoshinori

  Faculty Of Agriculture Kyushu University

• Yamada K

  Faculty Of Engineering Okayama University:(present Address)department Of Biotechnology And Life Scie

• KOBAYASHI Satomi

  Faculty of Agriculture, Kyushu University

• OGAWA Naoto

  Faculty of Agriculture, Kyushu University

• Ogawa Naoto

  Faculty Of Agriculture Kyushu University

• Tachibana H

  Faculty Of Agriculture Kyushu University

• Katayama Y

  Graduate School Of Bio-applications And Systems Engineering Tokyo University Of Agriculture And Tech

• Tian Huaize

  Department Of Bioscience And Biotechnology Faculty Of Agriculture Kyushu University

• Kobayashi Satomi

  Faculty Of Agriculture Kyushu University

• Yamada Koji

  Faculty Of Engineering Saitama University

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