E1A and ras Oncogenes Synergistically Enhance Recombinant Protein Production under Control of the Cytomegalovirus Promoter in BHK-21 Cells
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概要
- 論文の詳細を見る
The amplified ras oncogene greatly enhanced the production of recombinant human interleukin-6 (hIL-6) under control of the cytomegalovirus immediate early promoter (CMV promoter) in BHK-21 cells. When the adenovirus E1A oncogene was further transfected into the above mentioned ras-amplified hIL-6 hyper-producing BHK cells, the transfectants had about 10 times higher productivity than non-transfectants. However, the E1A gene alone did not enhance productivity. These results implicate a ras and E1A synergistic ability that acts to enhance hIL-6 production.
- 社団法人日本農芸化学会の論文
- 1995-02-23
著者
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OSADA Kazuhiro
Graduate School of Genetic Resources Thechnolgy, Kyushu University
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Tachibana H
Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B
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Tachibana Hirofumi
九州大学 農学部生物機能化学食糧化学
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Tachibana Hirofumi
Graduate School Of Genetic Resources Technology Kyushu University
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Kim E‐h
Korea Univ. Chung Nam Kor
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Osada K
Yakult Central Inst. Tokyo Jpn
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Osada Kazuhiro
Laboratory Of Cellular Regulation Technology Graduate School Of Genetic Resources Technology Kyushu
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Osada Kazuhiro
Graduate School Of Genetic Resources Technology Kyushu University
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SHIRAHATA Sanetaka
Graduate School of Genetic Resources Technology, Faculty of Agriculture, Kyushu University
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OHASHI Hideya
Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd.
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TERUYA Kiichiro
Graduate School of Systems Life Sciences, Kyushu University
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Murakami Hiroki
Graduate School of Genetic Resources Technology, Kyushu University
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Watanabe Junko
Graduate School of Genetic Resources Technology, Kyushu University
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Yano Takahiro
Graduate School of Genetic Resources Technology, Kyushu University
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Kim Eun-Ho
Department of Biotechnology, Korea University
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Kim Eun-ho
Department Of Biotechnology Korea University
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Murakami H
Kyushu Univ. Fukuoka Jpn
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Murakami H
Graduate School Of Genetic Resources Technology Kyushu University
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Murakami Hiroki
Laboratory Of Food Chemistry Faculty Of Agriculture Kyushu University
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OHASHI Hideo
Faculty of Agriculture, Gifu University
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Osada Kazuhiro
Department Of Genetic Resources Technology Faculty Of Agriculture Kyushu University
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Tachibana Hirofumi
Department Of Food Science And Technology Faculty Of Agriculture Kyushu University
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Yano T
Department Of Applied Biological Chemistry The University Of Tokyo
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Watanabe J
Food Function Division National Food Research Institute
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Ohashi H
Kirin Brewery Co. Ltd. Gunma Jpn
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Ohashi Hideya
Pharmaceutical Research Laboratory Kirin Brewery Co. Ltd.
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Teruya Kiichiro
Fac. Of Agriculture Kyushu Univ.
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Shirahata Sanetaka
Graduate School Of Systems Life Sciences Kyushu University:department Of Genetic Resources Technolog
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Shirahata S
Fac. Of Agriculture Kyushu Univ.
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Shirahata Sanetaka
Graduate School Of Genetic Resources Technology Faculty Of Agriculture Kyushu University
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Murakami Hiroki
Graduate School Of Genetic Resources Technology Kyushu University
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Murakami Hiroki
Graduate School Of Genetic Resources Technology Faculty Of Agriculture Kyushu University
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Watanabe J
Department Of Mathematical And Life Science Graduate School Of Sciense Hiroshima University
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Yano Takahiro
Graduate School Of Engineering Kyushu University
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Teruya Kiichiro
Graduate School Of Bioresource And Bioenvironmental Sciences Kyushu University
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Tian Huaize
Department Of Bioscience And Biotechnology Faculty Of Agriculture Kyushu University
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Yano Takahiro
Graduate School Of Electro-communications The University Of Electro-communications
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SHIRAHATA Sanetaka
Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University
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