Identification of Genes Involved in the Suppression of Antibody Production from Human Peripheral Blood Lymphocytes
スポンサーリンク
概要
- 論文の詳細を見る
Pretreatment with L-leucyl-L-leucine methyl ester (LLME) is a prerequisite for peripheral blood mononuclear cells (PBMCs) to produce antigen-specific antibodies when sensitized with an antigen. Little information, however, is available regarding the mechanisms involved in LLME-induced augmentation of antibody production from PBMCs that are antigen sensitized. In the present study, we attempted to identify the genes involved in the suppression of antibody production from PBMCs that was not treated with LLME, but sensitized with an antigen. Using subtractive screening, we obtained 63 independent genes, including 17 EST genes, that are specific for LLME-nontreated PBMC. Among these genes, the expression of heavy chain ferritin (H-ferritin), CC chemokine ligand 18 (CCL18), and matrix metalloproteinase 12 (MMP12) were augmented in LLME-nontreated PBMCs, suggesting that inflammatory factors might be involved in the suppression of antibody production in LLME-nontreated PBMCs.
- 社団法人 日本農芸化学会の論文
- 2006-04-23
著者
-
Aiba Yoshihiro
Graduate School Of Systems Life Sciences Faculty Of Agriculture Kyushu University
-
SHIRAHATA Sanetaka
Graduate School of Genetic Resources Technology, Faculty of Agriculture, Kyushu University
-
Katakura Y
Fac. Of Agriculture Kyushu Univ.
-
TERUYA Kiichiro
Graduate School of Systems Life Sciences, Kyushu University
-
KATAKURA Yoshinori
Graduate School of Systems Life Sciences, Kyushu University
-
YAMASHITA Makiko
Graduate School of Systems Life Sciences, Faculty of Agriculture, Kyushu University
-
MATSUMOTO Shin-ei
Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University
-
FURUKAWA Yuki
Graduate School of Systems Life Sciences, Faculty of Agriculture, Kyushu University
-
MATSUMOTO Shin-ei
Graduate School of Systems Life Sciences, Faculty of Agriculture, Kyushu University
-
TOMIMATSU Kousuke
Graduate School of Systems Life Sciences, Faculty of Agriculture, Kyushu University
-
Furukawa Yuki
Graduate School Of Systems Life Sciences Faculty Of Agriculture Kyushu University
-
Teruya Kiichiro
Fac. Of Agriculture Kyushu Univ.
-
Shirahata Sanetaka
Graduate School Of Systems Life Sciences Kyushu University:department Of Genetic Resources Technolog
-
Shirahata S
Fac. Of Agriculture Kyushu Univ.
-
Shirahata Sanetaka
Graduate School Of Genetic Resources Technology Faculty Of Agriculture Kyushu University
-
Tomimatsu Kosuke
Graduate School Of Systems Life Sciences Kyushu Univ.
-
Komatsu Takaaki
Department Of Genetic Resources Technology Faculty Of Agriculture Kyushu University
-
Yamashita Makiko
Fac. Of Agriculture Kyushu Univ.
-
Yamashita Makiko
Graduate School Of Genetic Resources Technology Kyushu University
-
Katakura Yoshinori
Dep. Of Genetic Resources Technol. Fac. Of Agriculture Kyushu Univ.
-
Maeyama Yoshiaki
R & D Division Nippon Luna Inc.
-
Tomimatsu Kosuke
Graduate School Of Systems Life Sciences Kyushu University
-
Katakura Yoshinori
Graduate School Of Bioresource And Bioenvironmental Sciences Kyushu University
-
Teruya Kiichiro
Graduate School Of Bioresource And Bioenvironmental Sciences Kyushu University
-
Yamashita Makiko
R & D Division Nippon Luna Inc.
-
Furukawa Yuki
Graduate School Of Chemical Sciences And Engineering Hokkaido University
-
SHIRAHATA Sanetaka
Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University
関連論文
- High Performance DC Superconducting Quantum Interference Device Utilizing a Bicrystal Junction with a 30° Misorientation Angle
- Inhibitory Effect of Electrolyzed Reduced Water on Tumor Angiogenesis(Molecular and Cell Biology)
- IL-10 Augments Antibody Production in in Vitro Immunized Lymphocytes by Inducing a Th2-Type Response and B Cell Maturation
- Effects of Herbacitrin, a Flavonoid, on the Growth of Normal and Transformed Serum-Free Mouse Embryo Cells(Biological Chemistry)
- Protein Kinase C δ Plays a Key Role in Cellular Senescence Programs of Human Normal Diploid Cells
- Anti-Peptide Antibody Production Elicited by in Vitro Immunization of Human Peripheral Blood Mononuclear Cells
- Identification of Genes Involved in the Suppression of Antibody Production from Human Peripheral Blood Lymphocytes
- Decreased Tumorigenicity In Vivo When Transforming Growth Factor β Treatment Causes Cancer Cell Senescence(Biochemistry & Molecular Biology)
- Efficient Production of Recombinant Human Erythropoietin by Replenishment of Microcarriers in the Hollow Fiber Culture Cassette
- Production of Recombinant Human Monoclonal Antibody Using ras-Amplified BHK-21 Cells in a Protein-free Medium
- PE-220 Intravenous Injection of Monteplase Followed by PCI Improves Long Term Outcome in Patients Without Microvascular Circulation Disturbance.(Acute Myocardial Infarction, Clinical (Diagnosis/Treatment) 12 (IHD) : PE38)(Poster Session (English))
- OJ-143 Injection of Monteplase Prior to PCI Prevents No Reflow Phenomenon in Acute Myocardial Infaraction (AMI)(Acute Myocardial Infarction, Clinical (Diagnosis/Treatment) 4 (IHD) : OJ17)(Oral Presentation (Japanese))
- Generation of Monoclonal Antibodies for Detection of a Kuchiziro Fish Virus of Tiger Puffer (Takifugu rubripes)
- The Protective Effect of Fermented Milk Kefir on Radiation-induced Apoptosis in Colonic Crypt Cells of Rats
- The protective effect of a fermented milk Kefir to radiation-induced apoptosis in rat colon
- Development of Serum-free Medium for Clonal Growth of Human-human Hybridomas
- E1A and ras Oncogenes Synergistically Enhance Recombinant Protein Production under Control of the Cytomegalovirus Promoter in BHK-21 Cells
- Ras Amplification in BHK-21 Cells Produces a Host Cell Line for Further Rapid Establishment of Recombinant Protein Hyper-producing Cell Lines
- Stimulation of Interferon β Production of Cultured Cells by Phospholipids in Foodstuffs
- Generation of Human-mouse Hybridoma Secreting Human IgM Class Anti-neocarzinostain Anti-body and Its Application to Hybrid Hybridoma(Biological Chemistry)
- Changes in Specificities of Human Monoclonal Antibodies by Introduction of Drug-resistance Gene into Hybridomas(Biological Chemistry)
- Production of a Recombinant Human Monoclonal Antibody Using a Novel Hollow Fiber Bioreactor System
- Effect of Immunoglobulin Production Stimulating Factors in Foodstuffs on Immunoglobulin Production of Human Lymphocytes(Food & Nutrition)
- Screening of Immunoglobulin Production Stimulating Factor (IPSF) in Foodstuffs Using Human-human Hybridoma HB4C5 Cells(Food & Nutrition)
- Extension of the Lifespan of Caenorhabditis elegans by the Use of Electrolyzed Reduced Water
- Multiplication of Bovine Viruses in Hamster Lung HmLu-1 Cells Cultured in Protein-free Medium(Microbiology & Fermentation Industry)
- Development of a Protein-free Medium with Ferric Citrate Substituting Transferrin for the Cultivation of Mouse-Mouse Hybridomas(Food & Nutrition)
- Stimulation and Inhibition of Interferon-β Production of Human Diploid Fibroblasts by Foodstuffs(Food & Nutrition)
- Establishment and Characterization of Monoclonal Antibodies Against Bovine Ephemeral Fever Virus(Biological Chemistry)
- Proliferation-stimulating Activity of Detergents Having Oleic Acid Residues in Serum-free Culture of Mammalian Cells(Biological Chemistry)
- Production of DNA-breaking Substance after Treatment of Monophenols with Sodium Nitrite and then with Dimethyl Sulfoxide(Biological Chemistry)
- Preparations of Histone and Nucleosome
- Propionibacterium Acnes Acts as an Adjuvant in in Vitro Immunization of Human Peripheral Blood Mononuclear Cells
- Production of Human Monoclonal Antibodies against FcεRIα by a Method Combining in Vitro Immunization with Phage Display
- Detection of Magnetic Nanoparticles with Superconducting Quantum Interference Device (SQUID) Magnetometer and Application to Immunoassays
- Properties of Josephson Junction Fabricated on Bicrystal Substrate with Different Misorientation Angles
- Production of Human Monoclonal Antibodies against FcεRIα by a Method Combining in Vitro Immunization with Phage Display
- Anti-Peptide Antibody Production Elicited by in Vitro Immunization of Human Peripheral Blood Mononuclear Cells
- Propionibacterium Acnes Acts as an Adjuvant in in Vitro Immunization of Human Peripheral Blood Mononuclear Cells
- Extension of the Lifespan of Caenorhabditis elegans by the Use of Electrolyzed Reduced Water
- Efficacy of Lactobacillus plantarum Strain HSK201 in Relief from Japanese Cedar Pollinosis
- Generation of a Human Anti-Tumor Necrosis Factor-α Monoclonal Antibody by in Vitro Immunization with a Multiple Antigen Peptide
- Pro-Senescent Effect of Hydrogen Peroxide on Cancer Cells and Its Possible Application to Tumor Suppression
- Construction of a Regulatable Cancer-Specific Adenoviral Expression System Using Human Telomerase Reverse Transcriptase Gene Promoter
- Increased Antibody Production by Retinoids Is Related to the Fusion Partner of Human Hybridomas(Biochemistry & Molecular Biology)
- Establishment of a Novel Method of Screening Anti-Allergic Lactic Acid Bacteria
- Mechanism of the Lifespan Extension of Caenorhabditis elegans by Electrolyzed Reduced Water-Participation of Pt Nanoparticles
- Preparation of Lipophilic Anionic Polymer Networks Based on Tetraphenylborates
- Identification of Immunopotentiating Lactic Acid Bacteria that Induce Antibody Production by in vitro Stimulated Human Peripheral Blood Mononuclear Cells