Identification of Genes Involved in the Suppression of Antibody Production from Human Peripheral Blood Lymphocytes

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概要

• 論文の詳細を見る

• Pretreatment with L-leucyl-L-leucine methyl ester (LLME) is a prerequisite for peripheral blood mononuclear cells (PBMCs) to produce antigen-specific antibodies when sensitized with an antigen. Little information, however, is available regarding the mechanisms involved in LLME-induced augmentation of antibody production from PBMCs that are antigen sensitized. In the present study, we attempted to identify the genes involved in the suppression of antibody production from PBMCs that was not treated with LLME, but sensitized with an antigen. Using subtractive screening, we obtained 63 independent genes, including 17 EST genes, that are specific for LLME-nontreated PBMC. Among these genes, the expression of heavy chain ferritin (H-ferritin), CC chemokine ligand 18 (CCL18), and matrix metalloproteinase 12 (MMP12) were augmented in LLME-nontreated PBMCs, suggesting that inflammatory factors might be involved in the suppression of antibody production in LLME-nontreated PBMCs.

• 社団法人 日本農芸化学会の論文
• 2006-04-23

著者

• Aiba Yoshihiro

  Graduate School Of Systems Life Sciences Faculty Of Agriculture Kyushu University

• SHIRAHATA Sanetaka

  Graduate School of Genetic Resources Technology, Faculty of Agriculture, Kyushu University

• Katakura Y

  Fac. Of Agriculture Kyushu Univ.

• TERUYA Kiichiro

  Graduate School of Systems Life Sciences, Kyushu University

• KATAKURA Yoshinori

  Graduate School of Systems Life Sciences, Kyushu University

• YAMASHITA Makiko

  Graduate School of Systems Life Sciences, Faculty of Agriculture, Kyushu University

• MATSUMOTO Shin-ei

  Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University

• FURUKAWA Yuki

  Graduate School of Systems Life Sciences, Faculty of Agriculture, Kyushu University

• MATSUMOTO Shin-ei

  Graduate School of Systems Life Sciences, Faculty of Agriculture, Kyushu University

• TOMIMATSU Kousuke

  Graduate School of Systems Life Sciences, Faculty of Agriculture, Kyushu University

• Furukawa Yuki

  Graduate School Of Systems Life Sciences Faculty Of Agriculture Kyushu University

• Teruya Kiichiro

  Fac. Of Agriculture Kyushu Univ.

• Shirahata Sanetaka

  Graduate School Of Systems Life Sciences Kyushu University:department Of Genetic Resources Technolog

• Shirahata S

  Fac. Of Agriculture Kyushu Univ.

• Shirahata Sanetaka

  Graduate School Of Genetic Resources Technology Faculty Of Agriculture Kyushu University

• Tomimatsu Kosuke

  Graduate School Of Systems Life Sciences Kyushu Univ.

• Komatsu Takaaki

  Department Of Genetic Resources Technology Faculty Of Agriculture Kyushu University

• Yamashita Makiko

  Fac. Of Agriculture Kyushu Univ.

• Yamashita Makiko

  Graduate School Of Genetic Resources Technology Kyushu University

• Katakura Yoshinori

  Dep. Of Genetic Resources Technol. Fac. Of Agriculture Kyushu Univ.

• Maeyama Yoshiaki

  R & D Division Nippon Luna Inc.

• Tomimatsu Kosuke

  Graduate School Of Systems Life Sciences Kyushu University

• Katakura Yoshinori

  Graduate School Of Bioresource And Bioenvironmental Sciences Kyushu University

• Teruya Kiichiro

  Graduate School Of Bioresource And Bioenvironmental Sciences Kyushu University

• Yamashita Makiko

  R & D Division Nippon Luna Inc.

• Furukawa Yuki

  Graduate School Of Chemical Sciences And Engineering Hokkaido University

• SHIRAHATA Sanetaka

  Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University

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