Enhancement of Production of IgM and Interferon-β in Human Cell Lines by Poly-lysine
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概要
- 論文の詳細を見る
The promotive effects of poly-cations on immunoglobulin production was investigated using human hybridoma cells. Among poly-cations tested, ε-poly-L-lysine with hydrochloride (approximately 4kDa), which has been used as an antibacterial food additive, had the greatest activity in enhancing IgM production of human-human hybridoma HB4C5 cells without stimulating cell proliferation. Immunoglobulin production stimulatory (IPS) activity of ε-poly-lysine was not affected by trypsin digestion. It was stable below 60℃ but completely inactivated with heating at 1000℃ for 30min. ε-Poly-lysine also enhanced interferon-β(IFN-β) production of human osteosarcoma MG-63 cells, but this stimulatory effect was reduced by the trypsin digestion.
- 社団法人日本農芸化学会の論文
- 1995-10-23
著者
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MAEDA YAMAMOTO
National Institute of Vegetable and Tea Sciences, National Agriculture and Food Research Organizatio
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OSADA Kazuhiro
Graduate School of Genetic Resources Thechnolgy, Kyushu University
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Osada Kazuhiro
Graduate School Of Genetic Resources Technology Kyushu University
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MORI YUTAKA
National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries
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Murakami Hiroki
Graduate School of Genetic Resources Technology, Kyushu University
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Maeda Yamamoto
National Research Institute Of Vegetables Ornamental Plants And Tea Ministry Of Agriculture Forestry
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Murakami Hiroki
Graduate School Of Genetic Resources Technology Faculty Of Agriculture Kyushu University
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Maeda Yamamoto
National Institute Of Vegetable And Tea Science
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Mori Yutaka
National Food Research Institute
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Mori Yutaka
National Food Research Institute Ministry Of Agriculture Forestry And Fisheries
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Murakami Hiroki
Graduate School of Genetic Resources Technology,Kyushu University
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