Constituents of Holothuroidea.9. Isolation and Structure of a New Ganglioside Molecular Species from the Sea Cucumber Holothuria pervicax
スポンサーリンク
概要
- 論文の詳細を見る
A new ganglioside molecular species, HPG-7 (1) was obtained from the polar fraction of the chloroform/methanol extract of the sea cucumber, Holothuria pervicax. On the basis of chemical and spectroscopic evidence, the structure of 1 was determined, and the major component was 1-O-[α-L-fucopyranosyl-(1→4)-(N-aceryl-α-D-neuraminosyl)-(2→11)-(N-glycolyl-α-D-neuraminosyl)-(2→4)-(N-acetyl-α-D-neuraminosyl)-(2→6)-β-D-glucopyranosyl]-(2S, 3S, 4R)-2-[(2R)-2-hydroxytetracosanoylamino]-14-methyl-hexadecane-1,3,4-triol. This is the first report on the isolation and structure elucidation of trisialo-ganglioside from sea cucumber. 1 showed neuritogenic activity toward the rat pheochromocytoma cell line, PC-12 cell.
- 公益社団法人日本薬学会の論文
- 2000-01-01
著者
-
Isobe R
Department Of Medical Electronics Engineering Faculty Of Engineering Towa University
-
Isobe Ryuichi
Tohwa University
-
YAMADA Koji
Faculty of Engineering, Saitama University
-
Miyamoto Tomofumi
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
-
Higuchi Ryuichi
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
-
Higuchi Ryuichi
Faculty Of Pharmaceutical Sciences Kyushu University
-
Yamada K
Graduate School Of Pharmaceutical Sciences Kyushu University
-
MIYAMOTO Tomofumi
Faculty of Pharmaceutical Sciences, Kyushu University
-
HARADA Yasuo
Faculty of Pharmaceutical Sciences, Kyushu University
-
Yamada Katsuya
Graduate School Of Pharmaceutical Sciences Nagoya City University
-
Isobe Ryuichi
Department Of Medical Electronics Engineering Faculty Of Engineering Towa University
-
Isobe R
Faculty Of Pharmaceutical Sciences Kyushu University
-
Harada Y
Administrator Of Hiroshima City Hospital Affairs Hiroshima
-
Maruta Tomoki
Graduate School Of Pharmaceutical Sciences Kyushu University
-
Harada Yasuo
Faculty Of Agriculture Kyushu University
-
Yamada Koji
Faculty Of Engineering Saitama University
関連論文
- Glyceroglycolipids Preventing tert-Butylhydroperoxide-Induced Cell Death from Microbacterium sp.and Corynebacterium aquaticum Strains
- Flavonoids from Brazilian Propolis
- Study on "Signal" Constituents for the Evaluation of Animal Crude Drugs. II. Organic Acids
- 高速液体クロマトグラフィーによるドリンク剤中の生薬成分の分析法.主要生薬成分の各分析法の検討
- Electrochemical Method for Estimating the Antioxidative Effects of Methanol Extracts of Crude Drugs
- Investigation of "Signal" Constituents for the Evaluation of Animal Crude Drugs. I. Free Amino Acids and Total Amino Acids
- Oleanene-Type Triterpene Glycosides from Puerariae Radix. IV. Six New Saponins from Pueraria lobata
- Oleanene-Type Triterpene Glycosides from Puerariae Radix. III.Three New Saponins from Pueraria thomsonii
- Three New Triterpenoidal Saponins Acylated with Monoterpenic Acid from Albizziae Cortex
- Activation of the Human Ah Receptor by Aza-Polycyclic Aromatic Hydrocarbons and Their Halogenated Derivatives
- A New Steroidal Saponin from Dioscorea cayenensis
- A New Phenanthrene Glycoside and Other Constituents from Dioscorea opposita
- Nucleophilic Substitution Reaction in Indole Chemistry: 1-Methoxy-6-nitroindole-3-carbaldehyde as a Versatile Building Block for 2,3,6-Trisubstituted Indoles
- Synthesis of Nb-acyltryptamines and their 1-hydroxy-tryptamine derivatives as new α2-blockers
- Influenza A Virus-Binding Activity of Glycoglycerolipids of Aquatic Bacteria
- High Field ESR and Magnetization in Na_2Co_2 (C_2O_4)_3(H_2O)_2(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- The Magnetic Property of a Uniaxial Spin-Ladder Material Na_2Fe_2(C_2O_4)_3(H_2O)_2(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- Diastereoselective Synthesis of (2R, 4R)-2-Aryl-4-hydroxypyrrolidine : Preparation of the Side Chain of Novel Carbapenem
- Synthesis of a Key Intermediate of Novel Galbonolide Analogues via Efficient Construction of a Conjugated Diene System
- Synthesis and Antifungal Activity of Novel 14-Membered Benzomacrolides, as Galbonolide Analogues
- Synthesis of the Side Chain of a Novel Carbapenem via Iodine-Mediated Oxidative Cyclization of (1R)-N-(1-Aryl-3-butenyl)acetamide
- Practical Synthesis of a 1β-Methylcarbapenem, J-111, 225, Using 4-Mercapto-2-[4-(N-methylaminomethyl)phenyl]pyrrolidine as a Precursor
- A Novel 1β-Methylcarbapenem, J-111,225 : Effects of the C-3 and C-5 Stereochemistry of the Pyrrolidinylthio Side Chain on Antibacterial Activities
- Imidazo- and Triazoloquinolones as Antibacterial Agents. Synthesis and Structure-Activity Relationships
- cis-Hinokiresinol, a Norlignan from Anemarrhena asphodeloides, Inhibits Angiogenic Response in Vitro and in Vivo (Pharmacognosy)
- 1,3-Dimethylisoguaninium, an Antiangiogenic Purine Analog from the Sponge Amphimedon paraviridis
- Isolation and Structures of Two New Compounds from the Essential Oil of Brazilian Propolis
- Characterization of Fe(III)-Deferoxamine and Mn(II)-Pectin as Magnetic Resonance Imaging Contrast Agents
- Regioselective Displacement Reactions of 1-Cyclopropyl-5,6,7,8-tetrafluoro-4(1H)-oxoquinoline-3-carboxylic Acid with Amine Nucleophiles
- Reactions of 1-Methoxy-3-(2-nitrovinyl)indole with Nucleophiles: An Interesting Solvent Effect and a Novel Preparation of 3-Substituted 1-Methoxyindoles
- The Chemistry of Indoles.CVII.A Novel Synthesis of3, 4, 5, 6-Tetrahydro-7-hydroxy-1H-azepino[5, 4, 3-cd]indoles and a New Finding on Pictet-Spengler Reaction
- The Chemistry of Indoles.CIII.^ Simple Syntheses of Serotonin, N-Methylserotonin, Bufotenine, 5-Methoxy-N-methyltryptamine, Bufobutanoic Acid, N-(Indol-3-yl)methyl-5-methoxy-N-methyltryptamine, and Lespedamine Based on 1-Hydroxyindole Chemistry
- Cytochrome P450 2E1/2A6-Selective Inhibition by Halogenated Anilines on Metabolic Activation of Dimethylnitrosamine in Human Liver Microsomes
- Inhibition of Human Cytochrome P450 2E1 by Halogenated Anilines, Phenols, and Thiophenols(Medicinal Chemistry)
- Water-soluble Component in Dried Chrysanthemum Flower Stimulates Tumor Necrosis Factor-α Production by Mouse Macrophage-like Cell Line RAW264.7
- Effect of 2,5-Dimethylpyrazine on Uterine Contraction in Late Stage of Pregnant Female Rats(Pharmacology)
- Isolation and Structure of a Galactocerebroside from the Sea Cucumber Bohadschia argus
- Isolation and Structure of a Monomethylated Ganglioside Possessing Neuritogenic Activity from the Ovary of the Sea Urchin Diadema setosum
- Biologically active gangliosides from echinoderms
- Determination of the Absolute Configuration of Sialic Acids in Gangliosides from the Sea Cucumber Cucumaria echinata
- Neuritogenic Activity of Gangliosides from Echinoderms and Their Structure : Activity Relationship
- Constituents of Holothuroidea, 18. Isolation and Structure of Biologically Active Disialo- and Trisialo-Gangliosides from the Sea Cucumber Cucumaria echinata
- Constituents of Holothuroidea, 17. Isolation and Structure of Biologically Active Monosialo-Gangliosides from the Sea Cucumber Cucumaria echinata
- Solvent effect on the reaction of 1-methoxy-3-(2-nitrovinyl)indole with nucleophiles
- Constituents of Holothuroidea, 16. : Determination of Absolute Configuration of the Branched Methyl Group in Ante-iso Type Side Chain Moiety on Long Chain Base of Glucocerebroside from the Sea Cucumber Holothuria leucospilota
- Constituents of Holothuroidea, 15 : Isolation of Ante-iso Type Regioisomer on Long Chain Base Moiety of Glucocerebroside from the Sea Cucumber Holothuria leucospilota
- Constituents of Holothuroidea, 14. Isolation and Structure of New Glucocerebroside Molecular Species from the Sea Cucumber Stichopus japonicus
- Novel syntheses of 1-hydroxy-6- and -5-nitroindole-3-carbaldehydes, and their derivatives as daikon-phytoalexin analogs
- Constituents of Holothuroidea, 13. Structure of Neuritogenic Active Ganglioside Molecular Species from the Sea Cucumber Stichopus chloronotus
- Nucleophilic substitution reactions of 1-methoxy-6-nitroindole-3-carbaldehyde 1
- Constituents of Holothuroidea, 12. Isolation and Structure of Glucocerebrosides from the Sea Cucumber Holothuria pervicax
- Synthesis of analogs of wasabi phytoalexin (methyl 1-methoxyindole-3-carboxylate)
- Inhibitory Effect of 2,5-Dimethylpyrazine on Oxytocic Agent -induced Uterine Hypercontraction of Normal or Pregnant Female Rats
- Synthesis of J-111,347,a Novel 1β-Methylcarbapenem with Broad-spectrum Antibacterial Activity
- Effects of Benzyl Glucoside and Chlorogenic Acid from Prunus mume on Adrenocorticotropic Hormone (ACTH) and Catecholamine Levels in Plasma of Experimental Menopausal Model Rats(Pharmacognosy)
- Effects of Benzyl Glucoside and Chlorogenic Acid from Prunus mume on Angiotensin Converting Enzyme, Aldosterone and Corticosterone Levels in Rat Plasma
- Inhibitory Effects of Benzyl Glucoside and Chlorogenic Acid from Prunus mume on Bradykinin and Prostaglandin E_2 Production in the Abdominal Cavities of Mice
- Identification of Sixteen New Galactocerebrosides from the Starfish Protoreaster nodosus
- Isolation and Structure of Hematoside-Type Ganglioside from the Starfish Linckia laevigata
- Constituents of Crinoidea. 5. Isolation and Structure of a New Glycosyl Inositolphosphoceramide-Type Ganglioside from the Feather Star Comanthina schlegeli
- Isolation and Structure of Four New Ceramides from the Starfish Luidia maculata
- P-536 Isolation and Structure of Phosphoglycosphingolipids from the Okinawan Feather Stars, Comanthina schlegeli and Comanthus bennetti
- Identification of Five Phytosterols from Aloe Vera Gel as Anti-diabetic Compounds(Pharmacognosy)
- Biologically Active Glycosides from Asteroidea, 42. Isolation and Structure of a New Biologically Active Ganglioside Molecular Species from the Starfish Asterina pectinifera
- Isolation and Structure of a Galactocerebroside Molecular Species from the Starfish Culcita novaeguineae
- Biologically Active Glycosides from Asteroidea, 43. : Isolation and Structure of a New Neuritogenic-Active Ganglioside Molecular Species from the Starfish Linckia laevigata
- Biologically Active Glycosides from Asteroidea, 41. : Isolation and Structure Determination of Glucocerebrosides from the Starfish Linckia laevigata
- Constituents of Crinoidea, 4. Isolation and Structure of Ceramides and Glucocerebrosides from the Feather Star Comanthus japonica
- Constituents of Crinoidea.3. Isolation and Structure of a Glycosyl Inositolphosphoceramide-Type Ganglioside with Neuritogenic Activity from the Feather Star Comanthus japonica
- Isolation and Structure of a GD_3-Type Ganglioside Molecular Species Possessing Neuritogenic Activity from the Starfish Luidia maculata
- Isolation and Structure of Monomethylated GM_3-Type Ganglioside Molecular Species from the Starfish Luidia maculata
- Collision-Activated Dissociation Spectra for the Characterization of the Diels-Alder Adducts between C_ and Troponoids
- Highly Thermally-Stable Diels-Alder Adducts of [60]Fullerene with 2-Cycloalkenones and Their Acetals
- Synthetic Studies on the Natural Multidrug Resistance Modulator, Irciniasulfonic Acid B
- Neuritogenic Activity-Guided Isolation of a Free Base Form Manzamine A from a Marine Sponge, Acanthostrongylophora aff. ingens(Thiele, 1899)
- Isolation and Structure Determination of Six Glucocerebrosides from the Starfish Luidia maculata
- Constituents of Ophiuroidea. 1. Isolation and Structure of Three Ganglioside Molecular Species from the Brittle Star Ophiocoma scolopendrina
- Differentiation of Diastereomeric Tertiarybutoxycarbonylprolylproline Ethyl Esters by Collision-Induced Dissociation of Sodium Adduct Ions in Fast Atom Bombardment Mass Spectrometry
- Constituents of Crinoidea.2. Isolation and Structure of the Novel Type Gangliosides from the Feather Star Comanthus japonica
- Constituents of Holothuroidea.10.^Isolation and Structure of a Biologically Active Ganglioside Molecular Species from the Sea Cucumber Holothuria leucospilota
- Differences in the Formation and Fragmentation of Sodium Adduct Ions between Tertiarybutoxycarbonyl-Protected Prolyproline Diastereomers in Fast Atom Bombardment Mass Spectrometry
- Constituents of Crinoidea. 1. Isolaton and Structure of Inositolphosphocermide from the Feather Star Comanthus japonica
- Structural Elucidation of Glycosphingolipids by Collision-Induced Dissociation of Sodium Ion Complex
- The Role of the Effective Mass in the Hot-Electron Magnetophonon Resonance in n-Type Germanium
- Steroidal Saponins from the Roots of Smilax aspera subsp. mauritanica
- Isolation and Structure Determination of cerebrosides from Garlic, the Bulbs of Allium sativum L.
- Fast Atom Bombardment Tandem Mass Spectrometry of Benzyloxycarbonyl-Protected Tetrapeptide Derivatives Containing Proline
- P-18 Search for Inhibitors of Prion Replication from Natural Resources
- Sulfated Lupane Triterpene Derivatives and a Flavone C-Glycoside from Gypsophila repens
- P-478 Sulfated lupane triterpene derivatives and a flavone C-glycoside from Gypsophila repens
- PA56 ISOLATION AND STRUCTURE OF THE THREE GANGLIOSIDES FROM THE STARFISH ACANTHASTER PLANCI
- Constituents of Holothuroidea.9. Isolation and Structure of a New Ganglioside Molecular Species from the Sea Cucumber Holothuria pervicax
- PA25 ISOLATION AND STRUCTURES OF NEWLY CHARACTERIZED OLIGOGLYCOSIDE SULFATES FROM ASTEROIDEA
- P-261 SYNTHETIC STUDY OF CHONDROSIAMIDE A, A CYCLIC DEPSIPEPTIDE FROM THE MARINE SPONGE CHONDROSIA CHUCALLA
- Two New Triterpene Saponins from Eryngium campestre
- Structural Elucidation of the Ceramide Moiety of Starfish Gangliosides by Collision-Induced Dissociation of the Sodium Ion Complex
- Litophynins I and J, Two New Biologically Active Diterpenoids from the Soft Coral Litophyton sp.
- Inhibitory Effect of Norditerpenes on LPS-Induced TNF-α Production from the Okinawan Soft Coral, Sinularia sp.
- Flavonoids from Brazilian Propolis
- Four New Cembrane Diterpenes Isolated from an Okinawan Soft Coral Lobophytum crassum with Inhibitory Effects on Nitric Oxide Production