Synthesis and Antifungal Activity of Novel 14-Membered Benzomacrolides, as Galbonolide Analogues
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概要
- 論文の詳細を見る
Asymmetric total synthesis of benzene analogues of galbonolide, a 14-membered antifungal macrolide, possessing a benzene ring instead of a conjugated diene structure, was achieved starting from chiral 1-aryl-1-propanol obtained by enzyme-catalyzed kinetic resolution with high enantioselectivity. Representatively, a method for the introduction of a methylthio and chloride function at the vinyl position was also established. The resulting analogues unfortunately exhibited very little antifungal potency in comparison with galbonolide A.
- 公益社団法人日本薬学会の論文
- 2004-01-01
著者
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Bamba-nagano Rie
Banyu Tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.
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SATO Hiromi
Tohoku College of Pharmacy
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SAKOH Hiroki
Banyu Tsukuba Research Institute
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SAKURABA Shunji
Banyu Tsukuba Research Institute
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IMAMURA Hideaki
Banyu Tsukuba Research Institute
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SUGIMOTO Yuichi
Banyu Tsukuba Research Institute
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YAMADA Koji
Banyu Tsukuba Research Institute
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MORISHIMA Hajime
Banyu Tsukuba Research Institute
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Sato H
Banyu Tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.
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JONA Hideki
Banyu Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd.
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HASHIZUME Terutaka
Banyu Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd.
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Sugimoto Yoshikazu
Hanno Research Center Taiho Pharmaceutical Co. Ltd.
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Yamada K
Graduate School Of Pharmaceutical Sciences Kyushu University
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Jona H
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
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Jona H
Banyu Tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.
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Jona Hideki
Banyu Tsukuba Research Institute
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Yamada Katsuya
Graduate School Of Pharmaceutical Sciences Nagoya City University
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Sakuraba S
Banyu Tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.
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Sugimoto Yuichi
Banyu Tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.
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Sakoh H
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
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Yamada Kenji
Tokyo University Of Pharmacy And Life Sciences School Of Pharmacy
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HASHIHAYATA Takashi
Center for Basic Research, The Kitasato Institute (TCI)
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Morishima H
Banyu Tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.
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Hashizume T
Banyu Tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.
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Hashihayata T
Center For Basic Research The Kitasato Institute (tci)
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Imamura H
Banyu Tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.
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