The Chemistry of Indoles.CVII.A Novel Synthesis of3, 4, 5, 6-Tetrahydro-7-hydroxy-1H-azepino[5, 4, 3-cd]indoles and a New Finding on Pictet-Spengler Reaction

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概要

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• Serotonins were found to produce 3, 4, 5, 6-tetrahydro-7-hydroxy-1H-azepino[5, 4, 3-cd]indoles by simple heating with amines under an oxygen atmosphere. Serotonins also reacted with various aldehydes to provide 3, 4, 5, 6-tetrahydro-7-hydroxy-1H-azepino[5, 4, 3-cd]indoles rather than β-carbolines under basic conditions. In these novel reactions, the presence of the 5-hydroxy group on the indole nucleus was suggested to be essential. Possible mechanisms are discussed.

• 公益社団法人日本薬学会の論文
• 2001-09-01

著者

• YAMADA Koji

  Faculty of Engineering, Saitama University

• YAMADA Fumio

  Faculty of Pharmaceutical Sciences, Kanazawa University

• SOMEI Masanori

  Faculty of Pharmaceutical Sciences, Kanazawa University

• TERANISHI Sakiko

  Faculty of Pharmaceutical Sciences, Kanazawa University

• Yamada K

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Somei Masanori

  Faculty Of Pharmaceutical Sciences Kanazawa University

• Yamada Katsuya

  Graduate School Of Pharmaceutical Sciences Nagoya City University

• Yamada Fumio

  Faculty Of Engineering Sizuoka University

• Yamada Koji

  Faculty Of Engineering Saitama University

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