Inhibitory Effect of Norditerpenes on LPS-Induced TNF-α Production from the Okinawan Soft Coral, Sinularia sp.
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概要
- 論文の詳細を見る
An ethanol (EtOH) extract of the soft coral (Sinularia sp.), collected in Okinawa, demonstrated a potent inhibitory effect on lipopolysaccharide (LPS)-induced tumor necrosis factor-α (TNF-α) production by murine macrophage-like cells (RAW264. 7). The activity-guided purification of the EtOH extract resulted in the isolation of two norditerpenes, norcembrenolide (1) and sinuleptolide (2). These structures were identified from the spectroscopic data. Norcembrenolide (1) and sinuleptolide (2) inhibited TNF-α production in a dose-dependent manner, and showed a more potent effect than prednisolone at the concentration of 33/μmI. They also exhibited an inhibitory effect on nitric oxide (NO) production not influenced by cytotoxicity.
- 公益社団法人日本薬学会の論文
- 2003-03-01
著者
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HIGUCHI Ryuichi
Graduate School of Pharmaceutical Sciences, Kyushu University
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Miyamoto Tomofumi
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
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Higuchi Ryuichi
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
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Higuchi Ryuichi
Graduate School Of Pharmaceutical Sciences Kyushu University
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Iwakawa You
Graduate School Of Pharmaceutical Sciences Kyushu University
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Miyamoto Tomofumi
Graduate School Of Pharmaceutical Sciences Kyushu University
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TAKAKI Hiroko
Graduate School of Pharmaceutical Sciences, Kyushu University
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KOGANEMARU Ryoji
Graduate School of Pharmaceutical Sciences, Kyushu University
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Takaki H
Fukuyama Univ. Hiroshima Jpn
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Koganemaru Ryoji
Graduate School Of Pharmaceutical Sciences Kyushu University
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Takai Hiroko
Graduate School of Pharmaceutical Sciences, Kyushu University
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