Isolation and Structure of a GD_3-Type Ganglioside Molecular Species Possessing Neuritogenic Activity from the Starfish Luidia maculata
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概要
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A GD_3-type ganglioside molecular species, LMG-4 (1), has been obtained from the polar lipid fraction of the chloroform/methanol extract of the starfish Luidia maculata. The structure of this ganglioside has been determined on the basis of chemical and spectroscopic evidence to be 1-O-[(N-acetyl-α-D-neuraminosyl)-(2→8)-(N-acetyl-α-D-neuraminosyl)-(2→3)-β-D-galactopyranosyl-(1→4)-β-D-glucopyranosyl]-ceramide. The ceramide moiety was composed of heterogeneous 2-hydroxy fatty acid and phytosphingosine units. This is the first report on the isolation and structure elucidation of GD_3-type ganglioside from echinoderms. Moreover, 1 exhibited neuritogenic activity toward the rat pheochromocytoma PC12 cells in the presence of nerve growth factor.
- 2004-08-01
著者
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INAGAKI MASANORI
Faculty of Pharmaceutical Sciences, Kyushu University
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HIGUCHI RYUICHI
Faculty of Pharmaceutical Sciences, Kyushu University
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Isobe R
Department Of Medical Electronics Engineering Faculty Of Engineering Towa University
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Isobe Ryuichi
Tohwa University
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Miyamoto Tomofumi
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
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Higuchi Ryuichi
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
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Higuchi Ryuichi
Faculty Of Pharmaceutical Sciences Kyushu University
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MIYAMOTO Tomofumi
Faculty of Pharmaceutical Sciences, Kyushu University
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ISOBE Ryuichi
Department of Medical Electronics Engineering, Faculty of Engineering, Towa University
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Isobe Ryuichi
Department Of Medical Electronics Engineering Faculty Of Engineering Towa University
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Isobe R
Faculty Of Pharmaceutical Sciences Kyushu University
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KAWATAKE Satoshi
Faculty of Pharmaceutical Sciences, Kyushu University
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Inagaki Masanori
Faculty Of Pharmaceutical Sciences Kyushu University
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Maruta Tomoki
Graduate School Of Pharmaceutical Sciences Kyushu University
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Ito Masaki
The First Department Of Internal Medicine Mie University School Of Medicine
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Kawatake Satoshi
Faculty Of Pharmaceutical Sciences Kyushu University
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