Analgesic Components of Glehnia Root (Glehnia littoralis)

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概要

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• Oral administration of a methanol extract of Glehnia root (Glehnia littoralis) prolonged pentobarbital-induced sleeping time, and the ethyl acetate fraction of the extract caused analgesic effect at a dose of 1 g/kg in mice. Bioassay-oriented separation of the extract gave, as the active components, polyacetylenes, panaxynol, falcarindiol and 8E-heptadeca-1,8-dien-4,6-diyn-3,10-diol, and coumarins, scopoletin, imperatorin, isoimperatorin, xanthotoxin, psoralen and bergapten. The polyacetylenes induced significant analgesia at doses of 10-50 mg/kg, and coumarins at doses of 80-100 mg/kg. Furocoumarins, except for psoralen, caused potent prolongation of the sleeping time at a dose of 10 mg/kg, due to inhibition of liver metabolizing enzymes. The composition of the components varies depending on the place of growth and the preparation method, which affects the pharmacological value of this herbal medicine.

• 日本生薬学会の論文
• 1998-12-20

著者

• 山崎 幹夫

  千葉大学薬学部

• 藤本 治宏

  千葉大院薬

• HAYASHI Masahiko

  The Kitasato Institute

• Natori Hiroko

  Faculty Of Pharmaceutical Sciences Chiba University

• Hayashi M

  The Kitasato Institute

• Homma M

  Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of

• 藤本 治宏

  Chiba Univ. Chiba Jpn

• Hasegawa Tetsuya

  Faculty Of Pharmaceutical Sciences Chiba University

• Okuyama Emi

  Faculty Of Pharmaceutical Science Chiba University

• MATSUSHITA Takamitsu

  Faculty of Pharmaceutical Sciences, Chiba University

• Matsushita T

  Faculty Of Pharmaceutical Sciences Chiba University

• OKUYAMA Emi

  Laboratory of Pharmacognosy, Faculty of Pharmaceutical Sciences, Josai International University

• Matsushita Takamitsu

  Faculty Of Pharmaceutical Sciences Chiba University

• Ito Masaki

  The First Department Of Internal Medicine Mie University School Of Medicine

• Okuyama E

  Laboratory Of Pharmacognosy Faculty Of Pharmaceutical Sciences Josai International University

• Fujimoto Haruhiro

  Faculty Of Pharmaceutical Sciences Chiba University

• ANETAI Masaki

  Hokkaido Institute of Public Health

• Ishibashi Masami

  Faculty Of Pharmaceutical Sciences Chiba University

• Yamazaki Mikio

  Faculty Of Pharmaceutical Sciences Chiba University

• HOSOKAWA Masakiyo

  Faculty of Pharmaceutical Sciences, Chiba University

• HIRAOKA Noboru

  Medicinal plant Garden, Niigata College of Pharmacy

• MASUDA Takahiro

  Graduate School of Environmental Earth Science, Hokkaido University

• TAKASUGI Mitsuo

  Graduate School of Environmental Earth Science, Hokkaido University

• Hasegawa Tetsuya

  Faculty Of Pharmaceutical Science Josai International University

• Masuda Takahiro

  Graduate School Of Environmental Earth Science Hokkaido University

• Takasugi Mitsuo

  Graduate School Of Environmental Earth Science Hokkaido University

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