Vimentin-Ser82 as a memory phosphorylation site in astrocytes
スポンサーリンク
概要
- 論文の詳細を見る
In astrocytes, the PGF(2 alpha) or ionomycin treatment induces the phosphorylation at Ser38 and Ser82 of vimentin, a type III intermediate filament, by Ca2+/calmodulin-dependent protein kinase II (CaMKII). We found here that vimentin phospho-Ser82 was dephosphorylated much slower than phospho-Ser38. Vimentin phospho-Ser38 was dephosphorylated quickly by purified PP1 catalytic subunit (PP1c) in vitro, whereas phospho-Ser82 was insensitive to PP1c. Because PP1c directly bound to vimentin through a VxF motif (Val83-Asp84-Phe85), the PP1c active site appeared to be unable to approach phospho-Ser82, leading to the prolongation of the phosphorylation at Ser-82. In astrocytes, PP1c alpha was in vivo associated with vimentin filaments. The repetitive treatment by ionomycin at a short interval resulted in the sustained elevation of Ser82 phosphorylation, leading to the marked disassembly of vimentin filaments. Taken together, these results suggest that vimentin is a novel member of binding partner of PP1c in astrocytes, and vimentin-Ser82 may act as a memory phosphorylation site.
- Blackwellの論文
著者
-
INAGAKI MASANORI
Faculty of Pharmaceutical Sciences, Kyushu University
-
Kikuchi Kunimi
Section Of Biochemistry Institute Of Immunological Science Hokkaido University
-
Kikuchi Kunimi
Institute Of Immumnological Science Hokkaido University
関連論文
- Glyceroglycolipids Preventing tert-Butylhydroperoxide-Induced Cell Death from Microbacterium sp.and Corynebacterium aquaticum Strains
- B cell Ag receptor mediates different types of signals in the protein kinase activity between immature B cell and mature B cell.
- Influenza A Virus-Binding Activity of Glycoglycerolipids of Aquatic Bacteria
- 1,3-Dimethylisoguaninium, an Antiangiogenic Purine Analog from the Sponge Amphimedon paraviridis
- Cycloanthranilylproline-Derived Constituents from a Myxomycete Fuligo candida
- Wrightiamines A and B, Two New Cytotoxic Pregnane Alkaloids from Wrightia javanica
- A New Secoiridoid Glucoside from Brucea amarissima
- Lindbladione and Related Naphthoquinone Pigments from a Myxomycete Lindbladia tubulina
- Isolation and Structure of a Galactocerebroside from the Sea Cucumber Bohadschia argus
- Isolation and Structure of a Monomethylated Ganglioside Possessing Neuritogenic Activity from the Ovary of the Sea Urchin Diadema setosum
- Biologically active gangliosides from echinoderms
- Determination of the Absolute Configuration of Sialic Acids in Gangliosides from the Sea Cucumber Cucumaria echinata
- Neuritogenic Activity of Gangliosides from Echinoderms and Their Structure : Activity Relationship
- Constituents of Holothuroidea, 18. Isolation and Structure of Biologically Active Disialo- and Trisialo-Gangliosides from the Sea Cucumber Cucumaria echinata
- Constituents of Holothuroidea, 17. Isolation and Structure of Biologically Active Monosialo-Gangliosides from the Sea Cucumber Cucumaria echinata
- Constituents of Holothuroidea, 16. : Determination of Absolute Configuration of the Branched Methyl Group in Ante-iso Type Side Chain Moiety on Long Chain Base of Glucocerebroside from the Sea Cucumber Holothuria leucospilota
- Constituents of Holothuroidea, 15 : Isolation of Ante-iso Type Regioisomer on Long Chain Base Moiety of Glucocerebroside from the Sea Cucumber Holothuria leucospilota
- Constituents of Holothuroidea, 14. Isolation and Structure of New Glucocerebroside Molecular Species from the Sea Cucumber Stichopus japonicus
- Isolation and Structure of Hematoside-Type Ganglioside from the Starfish Linckia laevigata
- Constituents of Crinoidea. 5. Isolation and Structure of a New Glycosyl Inositolphosphoceramide-Type Ganglioside from the Feather Star Comanthina schlegeli
- Isolation and Structure of Four New Ceramides from the Starfish Luidia maculata
- P-536 Isolation and Structure of Phosphoglycosphingolipids from the Okinawan Feather Stars, Comanthina schlegeli and Comanthus bennetti
- Identification of Five Phytosterols from Aloe Vera Gel as Anti-diabetic Compounds(Pharmacognosy)
- Biologically Active Glycosides from Asteroidea, 42. Isolation and Structure of a New Biologically Active Ganglioside Molecular Species from the Starfish Asterina pectinifera
- Isolation and Structure of a Galactocerebroside Molecular Species from the Starfish Culcita novaeguineae
- Biologically Active Glycosides from Asteroidea, 43. : Isolation and Structure of a New Neuritogenic-Active Ganglioside Molecular Species from the Starfish Linckia laevigata
- Biologically Active Glycosides from Asteroidea, 41. : Isolation and Structure Determination of Glucocerebrosides from the Starfish Linckia laevigata
- Constituents of Crinoidea, 4. Isolation and Structure of Ceramides and Glucocerebrosides from the Feather Star Comanthus japonica
- Constituents of Crinoidea.3. Isolation and Structure of a Glycosyl Inositolphosphoceramide-Type Ganglioside with Neuritogenic Activity from the Feather Star Comanthus japonica
- Isolation and Structure of a GD_3-Type Ganglioside Molecular Species Possessing Neuritogenic Activity from the Starfish Luidia maculata
- Isolation and Structure of Monomethylated GM_3-Type Ganglioside Molecular Species from the Starfish Luidia maculata
- Analgesic Components of Saposhnikovia Root : Saposhnikovia divaricata
- Six New Constituents from an Ascomycete, Chaetomlum quadrangulatum, Found in a Screening Study Focused on Monoamine Oxidase Inhibitory Activity
- Alterations in Type-1 Serine/ Threonine Protein Phosphatase PP1α in Response to B-Cell Receptor Stimulation
- Relationships of Subunits of Type-1 Serine/ Threonine Protein Phosphatase to Morphology and Aggregation of B Cells
- Thyrsiferyl 23-acetate is a novel specific inhibitor of protein phosphatase PP2A.
- Neoplastic alterations in subcellular distribution of type 1a protein phosphatase in rat ascites hepatoma cells
- プロテインホスファタ-ゼサブタイプ1β(PPP1CB)遺伝子のヒト,ラット及びマウス染色体上への位置づけ〔英文〕
- Chromosomal localization of human, rat, and mouse protein phospha @@S tase type 1β catalytic subunit genes (PPP1CB) by fluorescence in @@S ' situ hybridization.
- TGFβ1 suppresses EGF-induced increase in nuclear type 1 protein phosphatase activity at the G1/S transition of hepatocyte prolife @@S ration.
- Expressions and activities of protein phosphatases during
- Isolation and Structure Determination of Six Glucocerebrosides from the Starfish Luidia maculata
- Constituents of Ophiuroidea. 1. Isolation and Structure of Three Ganglioside Molecular Species from the Brittle Star Ophiocoma scolopendrina
- Differentiation of Diastereomeric Tertiarybutoxycarbonylprolylproline Ethyl Esters by Collision-Induced Dissociation of Sodium Adduct Ions in Fast Atom Bombardment Mass Spectrometry
- Constituents of Crinoidea.2. Isolation and Structure of the Novel Type Gangliosides from the Feather Star Comanthus japonica
- Differences in the Formation and Fragmentation of Sodium Adduct Ions between Tertiarybutoxycarbonyl-Protected Prolyproline Diastereomers in Fast Atom Bombardment Mass Spectrometry
- Constituents of Crinoidea. 1. Isolaton and Structure of Inositolphosphocermide from the Feather Star Comanthus japonica
- Structural Elucidation of Glycosphingolipids by Collision-Induced Dissociation of Sodium Ion Complex
- Separation of Leucas aspera, a Medicinal Plant of Bangladesh, Guided by Prostaglandin Inhibitory and Antioxidant Activities
- Isolation and Structure Determination of cerebrosides from Garlic, the Bulbs of Allium sativum L.
- Five New Chromones Possessing Monoamine Oxidase Inhibitory Activity from an Ascomycete, Chaetomium quadrangulatum
- Six Immunosuppressive Features from an Ascomycete, Zopfiella longicaudata. Found in a Screening Study Monitored by Immunomodulatory Activity
- Immunomodulatory Constituents from an Ascomycete, Emericella aurantio-brunnea
- ASSIGNMENT OF THE GENE ENCODING TYPE 1γ PROTEIN PHOSPHATASE CATALYTIC SUBUNIT (PPPlCC) ON HUMAN, RAT, AND MOUSE CHROMOSOMES
- 蛍光 in situ ハイブリダイゼーション法によるラットおよびマウスのプロテイン-チロシン・ホスファターゼPTPα/LRP遺伝子 (Ptpra) の染色体座位
- mRNA Levels and Enzyme Activities of Protein Phosphatases in Drug-Resistant Rat Ascites Hepatomas
- Regional localization of rat and mouse protein-tyrosine phosphatase PTPa/LRP gene (Ptpra) by fluorescence in situ hybridization
- Selective increases in isoform PP1α of type-1 protein phospha @@S tase in ascites hepatoma cells.
- Gene expression of protein phosphatases in rat ascites hepatoma cell lines.
- Vimentin-Ser82 as a memory phosphorylation site in astrocytes
- Alterations in Activity of Protein Tyrosine Phosphatase SH-PTP1 in Autoimmune MRL/MpJ-lpr/lpr Mice^1
- Gene Expressions of Protein Tyrosine Phosphatases in Regenerating Rat Liver and Rat Ascites Hepatoma Cells
- Gene Expressions of Protein Tyrosine Phosphatases in Regenerating Rat Liver and Rat Ascites Hepatoma Cells
- Tissue distribution of isoforms of type-1 protein phosphatase PP1 in mouse tissues and its diabetic alterations.
- IL-2 induces transient and specific decrease in cytosolic protein
- Alterations in activities of protein phosphatases PP1 and PP2A in
- A New Secoiridoid Glucoside from Brucea amarissima
- Isolation of Diphlorethohydroxycarmalol from a Brown Alga Ishige okamurae
- Cytotoxic Pregnanes from Leaves of Adenium obesum