Separation of Leucas aspera, a Medicinal Plant of Bangladesh, Guided by Prostaglandin Inhibitory and Antioxidant Activities
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概要
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According to the traditional usage of the plant for antiinflammation and analgesia, Leucas aspera was tested for its prostaglandin (PG) inhibitory and antioxidant activities. The extract showed both activities, i.e., inhibition at 3×10^<-4>g/ml against PGE_1- and PGE_2-induced contractions in guinea pig ileum and a 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging effect. The separation guided by the activities in these dual assay methods provided eight lignans and four flavonoids, LA-1--12, among which LA-1--7 and LA-10--12 were identified as nectandrin B, meso-dihydroguaiaretic acid, macelignan, acacetin, apigenin 7-ο-[6"-ο-(p-coumaroyl)-β-D-glucoside], chrysoeriol, apigenin, erythro-2-(4-allyl-2,6-dimethoxyphenoxy)-1-(4-hydroxy-3-methoxyphenyl)propan-1-ol, myristargenol B, and machilin C, respectively. LA-8 was determined to be (-)-chicanine, the new antipode of the (+) compound, by spectroscopic methods including CD and ORD. Chiral-HPLC analysis of LA-9 showed that it was a mixture of two enantiomers, (7R,8R)- and (7S,8S)-licarin A. All of these components were first isolated from L, aspera. PG inhibition was observed in LA-1, LA-2, and LA-5, and antioxidant activity in LA-1--3 and LA-8--12.
- 公益社団法人日本薬学会の論文
- 2003-05-01
著者
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Sadhu Samir
Pharmacy Discipline, Life Science School, Khulna University
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Ishibashi Masami
Graduate School of Pharmaceutical Sciences, Chiba University
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INAGAKI MASANORI
Faculty of Pharmaceutical Sciences, Kyushu University
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藤本 治宏
千葉大院薬
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奥山 恵美
千葉大学 院薬
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SADHU Samir
Graduate School of Pharmaceutical Sciences, Chiba University
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Sadhu Samir
Pharmacy Discipline Life Sci. School Khulna Univ.
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FUJIMOTO Haruhiro
Graduate School of Pharmaceutical Sciences, Chiba University
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藤本 治宏
Chiba Univ. Chiba Jpn
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OKUYAMA Emi
Graduate School of Pharmaceutical Sciences, Chiba University
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Ishibashi Masami
Graduate School Of Pharmaceutical Sciences Chiba Univ.
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Sadhu Samir
Graduate School Of Pharmaceutical Sciences Chiba University
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OKUYAMA Emi
Laboratory of Pharmacognosy, Faculty of Pharmaceutical Sciences, Josai International University
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Ito Masaki
The First Department Of Internal Medicine Mie University School Of Medicine
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Okuyama E
Laboratory Of Pharmacognosy Faculty Of Pharmaceutical Sciences Josai International University
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