Isolation and Characterization of Immunosuppressive Components of Three Mushrooms, Pisolithus tinctorius, Microporus flabelliformis and Lenzites betulina
スポンサーリンク
概要
- 論文の詳細を見る
Two components having an immunosuppressive activity were isolated together with non-active pisolactone from Pisolithus tinctorius, and they were deduced to be 24-methyllanosta-8,24(28)-diene-3β, 22ξ-diol and a mixture of two new compounds, (22S, 24R)-24-methyllanosta-8-en-22,28-epoxy-3β, 28α-diol and (22S, 24S)-24-methyllanosta-8-en-22,28-epoxy-3β, 28β-diol, respectively. Among them, pisolactone and 24-methyllanosta-8,24(28)-diene-3β, 22ξ-diol have previously been isolated from the same mushroom. Ergosterol peroxide and 9(11)-dehydroergosterol peroxide were also isolated as active components from this mushroom in small amounts, and from Microporus flabelliformis and Lenzites betulina. The IC_<50> values of these components were evaluated against proliferation of mouse spleen lymphocytes stimulated with concanavalin A and lipopolysaccharide.
- 公益社団法人日本薬学会の論文
- 1994-03-15
著者
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藤本 治宏
千葉大院薬
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山崎 幹夫
Faculty Of Pharmaceutical Sciences Chiba University
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山崎 幹夫
千葉大学薬学部医薬品素材学講座
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藤本 治宏
Faculty of Pharmaceutical Sciences, University of Tokyo
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中山 恵美
Faculty of Pharmaceutical Sciences, Chiba University
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中山 祐治
Faculty of Pharmaceutical Sciences, Chiba University
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藤本 治宏
Faculty Of Pharmaceutical Sciences University Of Tokyo
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中山 祐治
千葉大薬
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中山 祐治
Faculty Of Pharmaceutical Sciences Chiba University
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Nakayama M
Department Of Medicinal Chemistry Meiji Pharmaceutical University
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中山 恵美
Faculty Of Pharmaceutical Sciences Chiba University
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