Isolation of Some Immunosuppressive Components from an Ascomycete, Gelasinospora multiforis
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概要
- 論文の詳細を見る
Five new components, named multiforisins A, B, C, D, and E, with immunosuppressive activity were isolated from an Ascomycete, Gelasinospora multiforis. Multiforisin A, the main immunosuppressive principle of this fungus, was deduced to be 5-formyl-3-(hydroxymethyl)-4-methoxy-6-(1E-propenyl)-α-pyrone. Multiforisins B, C, D, and E were also deduced to be α-pyrone derivatives related to multiforisin A. The IC_<50> values of multiforisins A, B, C, D, E, and dihydro multiforisin A were evaluated against proliferation of mouse spleen lymphocytes stimulated with concanavalin A and lipopolysaccharide.
- 公益社団法人日本薬学会の論文
- 1995-04-15
著者
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藤本 治宏
千葉大院薬
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山崎 幹夫
Faculty Of Pharmaceutical Sciences Chiba University
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山崎 幹夫
千葉大学薬学部医薬品素材学講座
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佐藤 裕二
千葉大薬
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藤本 治宏
Faculty of Pharmaceutical Sciences, University of Tokyo
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佐藤 裕二
Faculty of Pharmaceutical Sciences, Chiba University
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中山 恵美
Faculty of Pharmaceutical Sciences, Chiba University
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TAKAYAMA Tomoe
Faculty of Pharmaceutical Sciences, Chiba University
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藤本 治宏
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Takayama T
Faculty Of Pharmaceutical Sciences Chiba University
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中山 恵美
Faculty Of Pharmaceutical Sciences Chiba University
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