6 Emericella属菌類の生産する抗真菌性エピジチオジオキソピペラジン誘導体Emestrinおよびその関連化合物
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概要
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Emericella striata 80-NE-22 is a fungus (Ascomycetes) isolated from cumin collected in Nepal. From its mycelial extract, novel macrocyclic epipolythiodioxopiperazines, emestrin (1) and emestrin B (2), were isolated along with shamixanthone, emericellin, sterigmatocystin, and paxilline. The structures of 1 and 2 were determined on the basis of the spectroscopic investi-gation of their derivatives and X-ray crystallography of emestrin methanol solvate. Emestrin (1) has strong antifungal activity, especially against Microsporum spp. and Trichophyton spp. Three compounds relating to 1, dethiosecoemestrin (3), aurantioemestrin (4) and violaceic acid (5), were isolated from the culture filtrate, and their structures were elucidated by the spectroscopic investigation. Isolation of dethiosecoemestrin (3) and aurantioemestrin (4) along with emestrin (1) and emestrin B (2) from the same fungus suggested the biodegradation of epidithiodioxopiperazines into trioxopiperazines. Emestrin (1) was also isolated from several species belonging to the genus Emericella; E. foveolata, E. quadilineata, E. acristata, and E. parvathecia.
- 天然有機化合物討論会の論文
- 1986-09-09
著者
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野沢 幸平
星薬大
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仲嶋 正一
星薬大
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河合 賢一
星薬大
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山崎 幹夫
千葉大生物活性研
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野沢 幸平
星薬科大学
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山崎 幹夫
Faculty Of Pharmaceutical Sciences Chiba University
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山崎 幹夫
千葉大学
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宇田川 俊一
Research Center For Pathogenic Fungi And Microbial Toxicoses Chiba University
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宇田川 俊一
国立衛試
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山田 美紀子
Hoshi College of Pharmacy
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瀬谷 秀之
星薬大
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法月 克弘
国立衛試
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Kawai Koji
Basic Research Laboratories Toray Industries Inc.
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瀬谷 秀之
Faculty of Pharmaceutical Sciences, Hoshi University
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仲嶋 正一
Faculty Of Pharmaceutical Sciences Hoshi University
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Nakajima S
Shionogi Research Laboratories Shinogi & Co. Ltd.
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瀬谷 秀之
Faculty Of Pharmaceutical Sciences Hoshi University
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