Sterochemistry of an 18,22-Cyclosterol, Mer-NF8054X, from Emericella heterothallica and Aspergillus ustus

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概要

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• An 18,22-cyclosterol, Mer-NF8054X (1), first isolated from a shaken culture of Aspergillus ustus as a strong antifungal agent with activity against Aspergillus fumigatus, was isolated from the culture filtrate of Emericella heterothallica. The absolute structure of 1 was established as 11-oxo-18,22-cycloergosta-6,8(14)-diene-3β, 5β, 9β, 23S-tetraol by spectroscopic and chemical investigation, and X-ray crystallographic analysis.

• 社団法人日本薬学会の論文
• 1995-01-15

著者

• 河合 賢一

  星薬大

• 河合 賢一

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 野沢 幸平

  Faculty of Pharmaceutical Sciences, Hoshi University

• 仲嶋 正一

  Faculty of Pharmaceutical Sciences, Hoshi University

• 河合 賢一

  Faculty Of Pharmaceutical Sciences Hoshi University

• 川原 信夫

  National Institute of Health Sciences (NIHS)

• 山崎 幹夫

  Faculty of Pharmaceutical Sciences, Chiba University

• 野沢 幸平

  星薬科大学

• 水野 礼子

  Faculty of Pharmaceutical Sciences, Hoshi University

• 山崎 幹夫

  Faculty Of Pharmaceutical Sciences Chiba University

• 山崎 幹夫

  千葉大学

• 山田 美紀子

  Hoshi College of Pharmacy

• 水野 礼子

  Faculty Of Pharmaceutical Sciences Hoshi University

• Mizuno Reiko

  Faculty Of Pharmaceutical Sciences Hoshi University

• 仲嶋 正一

  Faculty Of Pharmaceutical Sciences Hoshi University

• 川原 信夫

  National Institute Of Health Sciences

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