Structure of a Novel Epidithiodioxopiperazine, Emethallicin A, a Potent Inhibitor of Histamine Release, from Emericella heterothallica
スポンサーリンク
概要
- 論文の詳細を見る
A new epidithiodioxopiperazine derivative, emethallicin A (1), was isolated along with ergosterol from the mycelial extract of the heterothallic fungus, Emericella heterothallica (mating type A). The structure of emethallicin A (1) was established on the basis of chemical and spectroscopic investigations and finally by chemical transformation to apoaranotin (11). Emethallicin A (1) has the same basic skeleton as apoaranotin (11), with C_6-C_2 carboxylic acid (mandelic and phenylacetic acids) diester moieties, and showed a potent inhibitory activity on histamine release from mast cells.
- 社団法人日本薬学会の論文
- 1989-10-25
著者
-
河合 賢一
星薬大
-
河合 賢一
Faculty of Pharmaceutical Sciences, University of Tokyo
-
仲嶋 正一
Faculty of Pharmaceutical Sciences, Hoshi University
-
河合 賢一
Faculty Of Pharmaceutical Sciences Hoshi University
-
山崎 幹夫
Faculty of Pharmaceutical Sciences, Chiba University
-
川原 信夫
Faculty of Pharmaceutical Sciences, Hoshi University
-
山崎 幹夫
Faculty Of Pharmaceutical Sciences Chiba University
-
Kawai Koji
Basic Research Laboratories Toray Industries Inc.
-
仲嶋 正一
Faculty Of Pharmaceutical Sciences Hoshi University
-
Kawahara N
National Institute Of Health Sciences
-
Nakajima S
Shionogi Research Laboratories Shinogi & Co. Ltd.
関連論文
- 35 Emericella heterothallicaの産生する新規エピポリチオジオキソピペラジン誘導体およびその関連化合物(口頭発表の部)
- Chemical Studies on the Oriental Plant Drugs. XXVII. The Acid Catalyzed Reactions and the Absolute Configuration at C_ of Dammarane Type Triterpenes
- Isolation and Structures of Antibacterial Binaphtho-α-pyrones, Talaroderxines A and B, from Talaromyces derxii
- STRUCTURE REVISION OF MYCOTOXIN, VIRIDITOXIN, AND ITS DERIVATIVES
- 78(P-73) 細胞内情報伝達系に作用する南米産薬用植物の成分研究(ポスター発表の部)
- Structures of a New Dihydroxanthone Derivative, Nidulalin A, and a New Benzophenone Derivative, Nidulalin B, from Emericella nidulans
- Pharmacologically Active Components from a Peruvian Medicinal Plant, Huira-Huira (Culcitium canescens H. & B.)
- Ascaridole as a Pharmacologically Active Principle of "Paico", a Medicinal Peruvian Plant
- Analgesic Component of Notopterygium incisum TING
- ABSOLUTE STRUCTURE OF (+)-13β-HYDROXYMAMANITE, A POSSIBLE METABOLINE OF (-)-BAPTIFOLINE
- 1,3-Dipolar Cycloaddition Reactions of Thiazolo[5,4-d]pyrimidine 1-0xides with Acetylenic Esters Involving New Ring Transformations of the Thiazole Nucleus(Organic,Chemical)
- A Stereoselective Synthesis of the A, B, C-Ring System of a Triterpene, Pollinastanol
- Michael Reactions of 4-Acylmethylene-1,3 (2H, 4H)-isoquinolinediones with Malononitrile
- Michael Reactions of 3-Acylmethyleneoxindoles with Active Methylene Compounds
- Stereoselective Reduction of (S)-4-Isopropyl-3-phenacyl-1,3-oxazolidin-2-one by Means of 1,4-Asymmetric Induction : Synthesis of Chiral 2-Amino-1-phenylethanols
- Synthetic Study of the Ginseng Sapogenins : Preparation of Dammarenediol-II and Remote Oxidation of Dammaranediols with Photoexcited Nitrobenzene Derivatives
- Isolation and Structures of Two New Indoloditerpenes Related to Aflavinine from a Microsclerotium-Producing Strain of Aspergillus flavus
- Aspergillus novofumigatus から分離されたジヒドロテレインおよびテレインの血小板凝集作用に関する検討
- マルブランキア・フィラメントサから得られる2種の新規フラノン誘導体
- 好乾性真菌Aspergillus restrictus A17株のアレルゲン活性
- ブラジル土壌より分離されたアスペルジルス・フミガツスIFM 54246株から得られた抗真菌活性物質
- ネオサルトリア・フィッシェリからのイソテレインの単離
- 研究課題'04-23 真菌からの生理活性物質の探索(平成16年度 共同利用研究報告)
- 120(P-74) 未同定真菌IFM52672からの抗真菌物質の分離と構造決定(ポスター発表の部)
- 468 気管支喘息患者における好乾菌Asperugillus restrictus RAST 陽性率の検討
- 467 好乾菌Aspergillus restrictusの産生するアレルゲン活性検討
- A New Azaphilone, Falconensin H, from Emericella falconensis
- Falconensins A, B, C, and D, New Compounds Related to Azaphilone, from Emericella falconensis
- Structures of New Indoloditerpenes, Possible Biosynthetic Precursors of the Tremorgenic Mycotoxins, Penitrems, from Penicillium crustosum
- Sterochemistry of an 18,22-Cyclosterol, Mer-NF8054X, from Emericella heterothallica and Aspergillus ustus
- Structures of Novel Epipolythiodioxopiperazines, Emethallicins B, C, and D, Potent Inhibitors of Histamine Release, from Emericella heterothallica
- Structure of a Novel Epidithiodioxopiperazine, Emethallicin A, a Potent Inhibitor of Histamine Release, from Emericella heterothallica
- Studies on Fungal Products. XVIII. : Isolation and Structures of a New Fungal Depsidone Related to Nidulin and a New Phthalide from Emericella unguis
- Studies on Fungal Products. XVI. : New Metabolites Related to 3-Methylorsellinate from Aspergillus silvaticus
- Pharmacologically Active Components of Todopon Puok (Fagraea racemosa), a Medicinal Plant from Borneo
- A-33 ヒト肝ミクロゾームの薬物代謝能におよぼす Notopterol の影響
- CONVULSANTS FROM STAR ANISE (ILLICIUM VERUM HOOK.F.)
- 68 Monascus ankaの産生するMAO阻害活性物質(ポスター発表の部)
- Analgesic Components from Bornean Medicinal Plants, Tabernaemontana pauciflora BLUME and Tabernaemontana pandacaqui POIR
- Analgesic Principles from Aralia cordata THUNB.
- インドネシア産生薬の薬理活性成分に関する研究(第3報)Brucea javanica(L.)MERR.の毒性成分
- インドネシア産生薬の抗拘束水浸ストレス潰瘍活性成分の研究(第1報)Artocarpus integra MERR.(ヒメハラミツ)から(±)-Catechinの単離と同定
- Application of High-Performance Liquid Chromatography Using Water-Containing Silica Gel Columns for Large-Scale Preparation of Cerebroside
- The Principles of Tetragonia tetragonoides having Anti-ulcerogenic Activity. II. Isolation and Structure of Cerebrosides
- 蕃杏(ツルナ, Tetragonia tetragonoides)の抗拘束水浸ストレス潰瘍活性成分の研究(第1報)活性成分としてのSterylglucosides(Compound A)の分離と同定
- STRUCTURE OF ED-1 ISOLATED FROM EMERICELLA DENTATA
- Isolation and Structures of Oxaphenalenone Dimers from Talaromyces bacillosporus
- Isolation of Some New Tryptoquivaline-related Metabolites from Aspergillus fumigatus
- Studies on Pharmacologically Active Principles from Indonesian Crude Drugs. II. : Hypothermic Principle from Curcuma xanthorrhiza ROXB.
- Studies on Pharmacologically Active Principles from Indonesian Crude Drugs. I. : Principle Prolonging Pentobarbital-Induced Sleeping Time from Curcuma xanthorrhiza ROXB.
- ヤチヤナギからの新規トリテルペノイドMyricalactone及び数種のトリテルペノイド
- THREE NOVEL CYCLOLANOSTANOL XYLOSIDES FROM CIMICIFUGA RHIZOME
- Electrochemical Methoxylation of Arylacetates
- A New Lignan, (-)-Berchemol, from Berchemia racemosa
- A Novel Electrochemical Synthesis of Ureides from Esters
- Isolation of a New Tremorgenic Indologiterpene, 1'-O-Acetylpaxilline, from Emericella striata and Distribution of Paxilline in Emericella spp.
- 84(PA3-4) Emericella属菌類の生産する新規インドロジテルペン誘導体Emindole類およびその関連化合物(ポスター発表の部)
- A Novel Electrochemical Method of Acetylation of Alcohols by Methyl Acetate(Organic,Chemical)
- Studies on Fungal Products. XI. Isolation and Structures of Novel Cyclic Pentapeptides from Aspergillus sp. NE-45(Organic,Chemical)
- Studies on the Constituents of Beesia calthaefolia and Souliea vaginata. II. : Beesioside II, a Cyclolanostanol Xyloside from Rhizomes of Beesia calthaefolia
- 毒の博物誌-5-古代の覚醒剤ハオマ酒の秘密--エフェドリン
- "悪魔の贈りもの"煙草--ニコチン(毒の博物誌-8-)
- Microbial Reduction of 2-Phenylpropionic Acid, 2-Benzyloxypropionic Acid and 2-(2-Furfuryl) propionic Acid
- Microbial Reduction and Resolution of Herbicidal 2-Alkyl-2-aryloxyacetic Acids by Gloeosporium olivarum
- O-Methylation Effect on the Carbon-13 Nuclear Magnetic Resonance Signals of ortho-Disubstituted Phenols and Its Application to Structure Determination of New Phthalides from Aspergillus silvaticus
- MatrineおよびOxymatrineのストレス潰瘍抑制作用について, 特に中枢抑制に関する2,3の知見との関連
- Protosappanin A, a Novel Biphenyl Compound from Sappan Lignum
- 6 Emericella属菌類の生産する抗真菌性エピジチオジオキソピペラジン誘導体Emestrinおよびその関連化合物
- 薬学とマスメディア
- Studies on the Structure of Itaconitin. IV. The Reactions of Itaconitin and Anhydroitaconitin
- 18 Aspergillus itaconicusの色素,Itaconitin,の構造について
- Studies on the Structure of Itaconitin. III. : Identification of Organic Acids as p-Aminoazobenzene Derivatives. (2).
- Studies on the Structure of Itaconitin. II. Identification of Organic Acids as p-Aminoazobenzene Derivatives
- Studies on the Structure of Itaconitin. I.
- On the Nitration of Quinoxalines.
- 発癌物質研究夜話
- タラロマイセス・フラブスIFM52668株から得られる新フニコン誘導体
- Monoamine Oxidase Inhibitors from a Fungus : Emericella navahoensis
- ナガバノコウヤボウキから得られるセスキテルペノイドと青葉アルコール配糖体及びコウヤボウキのセスキテルペン配糖体
- 21世紀薬学像を探る
- 385 空中真菌相について : 気管支喘息児の家屋内夜間真菌分布
- 薬学を支えた薬科機器
- いま何故技術賞が必要か(日本薬学会賞技術賞[仮称]に対する希望)
- Emericella属における発がん性マイコトキシンsterigmatocystin類の生産性について
- オクテット
- 生薬を汚染する有害糸状菌について-2-製薬原料生薬を中心とした植物性生薬における糸状菌分布とマイコトキシンの生産性 (故浜田稔博士記念号-2-)
- 毒の博物誌-10-フロイト博士の失敗--コカイン
- 餅のカビ・米のカビ--黄変米カビ毒(毒の博物誌-6-)
- 毒の博物誌-4-蒼ざめた馬--タリウム
- アスペルジルス属菌IFM51759株から得られたフラノン及びピラノン誘導体のアスペルジルス・フミガツスに対する抗真菌活性
- Studies on Fungal Products. IX. : Dethiosecoemestrin, a New Metabolite Related to Emestrin, from Emericella striata
- 14 EBELIN LACTONE形成サポニンの真正サポゲニンについて
- Microbial Transformation of 2,4-D and Its Analogues
- Syntheses of Two Microbial Metabolites, 5-Chloro-3,4-dihydro-8-hydroxy-6-methoxy-3-methylisocoumarin and 8-Hydroxy-6-methoxy-3-methylisocoumarin
- Studies on the Metabolites of Phytotoxic Fungi. I. Isolation of Macrosporin and 6-Methylxanthopurpurin 3-Methyl Ether from Alternaria bataticola IKATA ex YAMAMOTO
- Studies on the Structure of Itaconitin. VIII. Synthesis of Methylanhydroitaconitin
- Studies on the Structure of Itaconitin. VII. The Structures of Itaconitin and Its Derivatives
- Studies on the Structure of Itaconitin. VI. The Structures of Anhydroitaconitin and Its Derivatives
- Studies on the Structure of Itaconitin. V. On the Alkaline Hydrogenation Product of Anhydroitaconitin
- 過ヨード酸およびシクロヘキシルアミンによる配糖体の加水分解法およびその糖部-非糖部結合決定の可能性