Identification of Immunosuppressive Components of a Mushroom, Lactarius flavidulus
スポンサーリンク
概要
- 論文の詳細を見る
Three metabolites having a suppressive effect on proliferation of mouse lymphocytes stimulated with mitogens such as concanavalin A (Con A) and lipopolysaccharide (LPS) were isolated from a mushroom, Lactarius flavidulus, and identified as geranylphenols, flavidulols A, B and C, respectively, which had previously been isolated from the same mushroom. The IC_<50> values of flavidulols A, B and C were found to be 8.9,4.9 and 36.3 μg/ml against Con A-induced proliferation of mouse lymphocytes, and 6.7,3.9 and 28.3 μg/ml against LPS-induced proliferation, respectively.
- 公益社団法人日本薬学会の論文
- 1993-04-15
著者
-
藤本 治宏
千葉大院薬
-
山崎 幹夫
Faculty Of Pharmaceutical Sciences Chiba University
-
山崎 幹夫
千葉大学薬学部医薬品素材学講座
-
藤本 治宏
Faculty of Pharmaceutical Sciences, University of Tokyo
-
中山 祐治
Faculty of Pharmaceutical Sciences, Chiba University
-
藤本 治宏
Faculty Of Pharmaceutical Sciences University Of Tokyo
-
中山 祐治
千葉大薬
-
中山 祐治
Faculty Of Pharmaceutical Sciences Chiba University
関連論文
- 35 Emericella heterothallicaの産生する新規エピポリチオジオキソピペラジン誘導体およびその関連化合物(口頭発表の部)
- New Toxic Metabolites from a Mushroom, Hebeloma vinosophyllum. II. Isolation and Structures of Hebevinosides VI, VII, VIII, IX, X, and XI(Organic,Chemical)
- New Toxic Metabolites from a Mushroom, Hebeloma vinosophyllum. I. : Structures of Hebevinosides I, II, III, IV, and V
- 69 アカヒダワカフサタケの毒性代謝産物hebevinoside類の単離と構造(その2)
- 9 アカヒダワカフサタケの毒性代謝産物hebevinoside類の単離と構造
- THE TOXIC PRINCIPLES OF NAEMATOLOMA FASCICULARE
- Chemistry of Tremorogenic Metabolites. II. Structure Determination of Fumitremorgin B, a Tremorogenic Metabolite from Aspergillus fumigatus
- 薬学100年
- Pharmacologically Active Components from a Peruvian Medicinal Plant, Huira-Huira (Culcitium canescens H. & B.)
- Ascaridole as a Pharmacologically Active Principle of "Paico", a Medicinal Peruvian Plant
- Analgesic Component of Notopterygium incisum TING
- 78(P-35) 子嚢菌Chaetomium quadrangulatumのモノアミン酸化酵素阻害活性成分(ポスター発表の部)
- Sterochemistry of an 18,22-Cyclosterol, Mer-NF8054X, from Emericella heterothallica and Aspergillus ustus
- Structures of Novel Epipolythiodioxopiperazines, Emethallicins B, C, and D, Potent Inhibitors of Histamine Release, from Emericella heterothallica
- Structure of a Novel Epidithiodioxopiperazine, Emethallicin A, a Potent Inhibitor of Histamine Release, from Emericella heterothallica
- Studies on Fungal Products. XVIII. : Isolation and Structures of a New Fungal Depsidone Related to Nidulin and a New Phthalide from Emericella unguis
- Pharmacologically Active Components of Todopon Puok (Fagraea racemosa), a Medicinal Plant from Borneo
- CONVULSANTS FROM STAR ANISE (ILLICIUM VERUM HOOK.F.)
- Analgesic Components from Bornean Medicinal Plants, Tabernaemontana pauciflora BLUME and Tabernaemontana pandacaqui POIR
- Analgesic Principles from Aralia cordata THUNB.
- 講座名あれこれ
- Studies on Pharmacologically Active Principles from Indonesian Crude Drugs. II. : Hypothermic Principle from Curcuma xanthorrhiza ROXB.
- Studies on Pharmacologically Active Principles from Indonesian Crude Drugs. I. : Principle Prolonging Pentobarbital-Induced Sleeping Time from Curcuma xanthorrhiza ROXB.
- Isolation of a New Tremorgenic Indologiterpene, 1'-O-Acetylpaxilline, from Emericella striata and Distribution of Paxilline in Emericella spp.
- 84(PA3-4) Emericella属菌類の生産する新規インドロジテルペン誘導体Emindole類およびその関連化合物(ポスター発表の部)
- 毒薬世相学
- 地震災害と実験室の安全対策
- 毒の博物誌-5-古代の覚醒剤ハオマ酒の秘密--エフェドリン
- "悪魔の贈りもの"煙草--ニコチン(毒の博物誌-8-)
- マイコトキシンの一種,デオキシニバレノールの土壌細菌による毒性低減化 : 微生物
- 111(P-58) 真菌由来α-ピロン環型天然物の立体化学(ポスター発表の部)
- MatrineおよびOxymatrineのストレス潰瘍抑制作用について, 特に中枢抑制に関する2,3の知見との関連
- 6 Emericella属菌類の生産する抗真菌性エピジチオジオキソピペラジン誘導体Emestrinおよびその関連化合物
- Studies on the Monoamine Oxidase (MAO) Inhibitory Potency of TL-1,Isolated from a Fungus, Talaromyces luteus
- モノアミン酸化酵素阻害活性を有するトロポロン関連化合物について
- 81(P-79) マユハキタケ科子嚢菌2種からの免疫調節活性成分の単離とその絶対配置(ポスター発表の部)
- 子嚢菌 Sordaria gondaensis の免疫抑制活性成分
- P-41 防風の鎮痛活性成分 II.
- 72(P47) Gelasinospora属子嚢菌3種からの免疫調節活性成分(ポスター発表の部)
- 薬学とマスメディア
- 子嚢菌 Emericella corrugata からの新毒性代謝産物
- 家伝薬いろいろ
- 61(P31) 子嚢菌Diplogelasinospora grovesii及び関連菌からの新免疫抑制活性成分(ポスター発表の部)
- P-60 子嚢菌Gelasinospora multiforis及びG. kobiからの新免疫抑制活性成分(ポスター発表の部)
- Isolation of Some Immunosuppressive Components from an Ascomycete, Gelasinospora multiforis
- 発癌物質研究夜話
- Four New Immunosuppressive Components, Kobiin and Kobifuranones A, B, and C, from an Ascomycete, Gelasinospora kobi
- 子のう菌 Talaromyces luteus より得られた新MAO阻害物質 Luteusin A と可逆的MAO-B阻害薬Ro16-6491との ex vivo におけるMAO阻害活性の比較検討
- Four New Chlorinated Azaphilones, Helicusins A-D, Closely Related to 7-epi-Sclerotiorin, from an Ascomycetous Fungus, Talaromyces helicus
- 子嚢菌 Gelasinospora pseudoreticulata 由来 Mycelia Sterilia からのモノアミン酸化酵素阻害活性成分
- Isolation and Characterization of Immunosuppressive Components of Three Mushrooms, Pisolithus tinctorius, Microporus flabelliformis and Lenzites betulina
- 38 子のう菌Talaromyces luteus、T. helicusより得られた新azaphilone代謝産物(口頭発表の部)
- Identification of Immunosuppressive Components of a Mushroom, Lactarius flavidulus
- Isolation, Identification and Pharmacological Studies on Three Toxic Metabolites from a Mushroom, Hebeloma spoliatum
- New Toxic Metabolites from a Mushroom, Hebeloma vinosophyllum. III. Isolation and Structures of Three New Glycosides, Hebevinosides XII, XIII and XIV, and Productivity of the Hebevinosides at Three Growth Stages of the Mushroom
- Monoamine Oxidase Inhibitors from a Fungus : Emericella navahoensis
- きのこの生理活性物質 (きのこの生物工学)
- 21世紀薬学像を探る
- 385 空中真菌相について : 気管支喘息児の家屋内夜間真菌分布
- 薬学を支えた薬科機器
- いま何故技術賞が必要か(日本薬学会賞技術賞[仮称]に対する希望)
- Emericella属における発がん性マイコトキシンsterigmatocystin類の生産性について
- オクテット
- まず体質を変えて事業にあたれ(学会事業の在り方)
- 生薬を汚染する有害糸状菌について-2-製薬原料生薬を中心とした植物性生薬における糸状菌分布とマイコトキシンの生産性 (故浜田稔博士記念号-2-)
- 小寺七郎さんの「私の戦争」
- 289 空中真菌相について : 気管支喘息児の家庭内真菌分布に関する検討(アレルゲン・抗原)
- Aspergillus fumigatusとその近縁菌における痙れん性カビ毒--fumitremorginA.B.の生産性
- 79 空中真菌相の研究(第1報) : 空中真菌の年間分布について(アレルゲン・抗原)
- 生薬を汚染する有害糸状菌について(第1報)市販生薬類における糸状菌分布と有害糸状菌におけるマイコトキシン生産性
- 考古学の中の毒と薬
- 子嚢菌由来のxanthone系免疫抑制活性成分について (第14回天然薬物の開発と応用シンポジウム 講演要旨集) -- (一般講演 天然資源と医薬品開発2)
- 毒の博物誌-10-フロイト博士の失敗--コカイン
- 餅のカビ・米のカビ--黄変米カビ毒(毒の博物誌-6-)
- 毒の博物誌-4-蒼ざめた馬--タリウム
- 毒の博物誌-3-踊った尼僧たち--幻覚性キノコ毒
- 毒の博物誌-1-マルコ・ポ-ロの「山の老人」--インド大麻
- 天然に薬を求めて--薬の素材 (薬をつくる化学)
- Wrightiamines A and B, Two New Cytotoxic Pregnane Alkaloids from Wrightia javanica
- Analgesic Components of Saposhnikovia Root : Saposhnikovia divaricata
- Six New Constituents from an Ascomycete, Chaetomlum quadrangulatum, Found in a Screening Study Focused on Monoamine Oxidase Inhibitory Activity
- Monoamine Oxidase Inhibitory Naphthoquinone and/or Naphthalene Dimers from Lemuni Hitam (Diospyros sp.), a Malaysian Herbal Medicine
- Immunomodulatory Constituents from an Ascomycete, Microascus tardifaciens
- Immunomodulatory Constituents from Three Ascomycetes, Gelasinospora heterospora, G. multiforis, and G. longispora
- Manoamine Oxidase Inhibitory constituents from Anixiella micropertusa
- Immunosuppressive Components from an Ascomycete, Diplogelasinospora grovesii
- Isolation of New Tremorgenic Metabolites from an Ascomycete, Corynascus setosus
- REVISED STEREOSTRUCTURES OF LUTEUSINS C AND D
- Separation of Leucas aspera, a Medicinal Plant of Bangladesh, Guided by Prostaglandin Inhibitory and Antioxidant Activities
- Monoamine Oxidase-Inhibitory Components from an Ascomycete, Coniochaeta tetraspora
- Isolation of Three New Azaphilones, Luteusins C, D, and E, from an Ascomycete, Talaromyces luteus
- Five New Chromones Possessing Monoamine Oxidase Inhibitory Activity from an Ascomycete, Chaetomium quadrangulatum
- Novel Syntheses of Murrayaquinone A and Furostifoline through 4-Oxygenated Carbazoles by Allene-Mediated Electrocyclic Reactions Starting from 2-Chloroindole-3-carbaldehyde
- Six Immunosuppressive Features from an Ascomycete, Zopfiella longicaudata. Found in a Screening Study Monitored by Immunomodulatory Activity
- Immunomodulatory Constituents from an Ascomycete, Emericella aurantio-brunnea
- New Syntheses of Murrayaquinone A and Furostifoline
- 薬学概論
- Analgesic Components of Glehnia Root (Glehnia littoralis)
- 癌をつくる植物毒 (生物毒)
- 子のう菌Talaromyces luteusより得られた新MAO阻害物質Luteusin Aと可逆的MAO-B阻害薬Ro16-6491とのex vivoにおけるMAO阻害活性の比較検討