子のう菌Talaromyces luteusより得られた新MAO阻害物質Luteusin Aと可逆的MAO-B阻害薬Ro16-6491とのex vivoにおけるMAO阻害活性の比較検討
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概要
- 論文の詳細を見る
Monoamine oxidase (MAO)-inhibitory activity of luteusin A (previous name TL-1), obtained from Talaromyces luteus (Ascomycete), was compared with those of known MAO-inhibitory compounds by in vitro, ex vivo and in vivo bioassays. Luteusin A, known to inhibit MAO-B reversibly in vitro, inhibited mouse brain MAO and liver MAOs in the ex vivo bioassay significantly. The mode of the inhibitory action seemed to be similar to that of Ro16-6491 and Ro19-6327, known reversible MAO-B inhibitors which are promising lead compounds as antiparkinsonism drugs.
- 日本生薬学会の論文
- 1996-02-20
著者
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山崎 幹夫
千葉大学薬学部
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藤本 治宏
千葉大学薬学部
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吉田 栄治
Faculty Of Pharmaceutical Sciences Chiba University
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藤本 治宏
千葉大院薬
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吉田 栄治
千葉大学薬学部
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