Immunomodulatory Constituents from an Ascomycete, Emericella aurantio-brunnea

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概要

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• Fractionation monitored by the immunomodulatory activity of the AcOEt extract of an Ascomycete, Emericella aurantio-brunnea, afforded two known fungal sesterterpenes, variecolin (1) and variecolactone (2), two new variecolin congeners named variecoacetals A (3) and B (4), and a new sesquiterpenetriol diester named emeremophiline (5), as the immunosuppressive constituests of this fungus. The absolute configuration of 1,which was previously not determined, was determined to be (2S, 3S, 6R, 10S, 11R, 14S, 15R, 16S) from the NMR spectral data of the (6R, 7R)-dimethyl-1,3,5-trioxacycloheptyl derivative of 1 (7). The absolute configurations of the other variecolin congeners, 2-4,and variecolol (6) are also proposed form biosynthetic considerations.

• 公益社団法人日本薬学会の論文
• 2000-10-01

著者

• INAGAKI MASANORI

  Faculty of Pharmaceutical Sciences, Kyushu University

• 藤本 治宏

  千葉大院薬

• 奥山 恵美

  千葉大学 院薬

• OKUYAMA Emi

  Faculty of Pharmaceutical Sciences, Chiba University

• FUJIMOTO Haruhiro

  Faculty of Pharmaceutical Sciences, Chiba University

• 藤本 治宏

  Chiba Univ. Chiba Jpn

• ISHIBASHI Masami

  Faculty of Pharmaceutical Sciences, Hokkaido University

• Ishibashi Masami

  Faculty Of Pharmaceutical Sciences Hokkaido University

• Okuyama Emi

  Faculty Of Pharmaceutical Science Chiba University

• Nakamura Etsuko

  Graduate School Of Pharmaceutical Sciences Chiba University

• OKUYAMA Emi

  Laboratory of Pharmacognosy, Faculty of Pharmaceutical Sciences, Josai International University

• NAKAMURA Etsuko

  Faculty of Pharmaceutical Sciences, Chiba University

• Ito Masaki

  The First Department Of Internal Medicine Mie University School Of Medicine

• Okuyama E

  Laboratory Of Pharmacognosy Faculty Of Pharmaceutical Sciences Josai International University

• Fujimoto Haruhiro

  Faculty Of Pharmaceutical Sciences Chiba University

• Ishibashi Masami

  Faculty Of Pharmaceutical Sciences Chiba University

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