Immunosuppressive Components from an Ascomycete, Diplogelasinospora grovesii
スポンサーリンク
概要
- 論文の詳細を見る
Two known fungal metabolites, macrophin and colletodiol, and a new stereoisomer of colletodiol named 10-epi-colletodiol, were isolated as immunosuppressive principles from an Ascomycete, Diplogelasinospora grovesii. The IC_<50> values of the major active component among them, macrophin, were calculated to be 0.4 and 0.3μg/ml against concanavalin A- and lipopolysaccharide-induced proliferations of mouse spleen lymphocytes, respectively. A new natural product, 4,8-dimethyl-1,5-dioxacyclooctane-2,6-dione, and a known fungal metabolite, isosclerone, which showed no immunosuppressive activity, were also isolated from this fungus.
- 公益社団法人日本薬学会の論文
- 1998-03-15
著者
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山崎 幹夫
千葉大学薬学部
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藤本 治宏
千葉大院薬
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山崎 幹夫
千葉大学薬学部医薬品素材学講座
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Yamaguchi K
Analysis Center Chiba University
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YAMAGUCHI Kentaro
Analysis Center, Chiba University
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YAMAZAKI Mikio
Faculty of Pharmaceutical Sciences, Chiba University
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FUJIMOTO Haruhiro
Faculty of Pharmaceutical Sciences, Chiba University
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藤本 治宏
Chiba Univ. Chiba Jpn
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Yamaguchi Kentaro
Analysis Center Chiba University
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NAGANO Junko
Faculty of Pharmaceutical Sciences, Chiba University
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Nagano Junko
Faculty Of Pharmaceutical Sciences Chiba University
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Fujimoto Haruhiro
Faculty Of Pharmaceutical Sciences Chiba University
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Yamazaki Mikio
Faculty Of Pharmaceutical Sciences Chiba University
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