Monoamine Oxidase Inhibitory Naphthoquinone and/or Naphthalene Dimers from Lemuni Hitam (Diospyros sp.), a Malaysian Herbal Medicine

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概要

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• From the extract of a Malaysian herbal medicine, Lemuni Hitam (Diospyros sp.), which exhibited monoamine oxidase (MAO) inhibition, three new naphthoquinone and/or naphthalene dimers (lemuninols A-C, 1-3) were isolated together with 4,6-dihydroxy-5-methoxy-2-methyl-naphthalene (8) and six known monomers (4-7,9 and 10). The structures were determined by spectroscopic methods including 2D-NMR techniques. Among them, lemuninol A showed 45% inhibition of MAO (mouse liver ) at 5.0×10^<-6> g/ml, and lemuninols B and C and a naphthoquinone (9) indicated weak activity. Some related quinones were also tested for their MAO inhibitory activities.

• 公益社団法人日本薬学会の論文
• 1999-10-15

著者

• 山崎 幹夫

  千葉大学薬学部

• 藤本 治宏

  千葉大院薬

• 山崎 幹夫

  千葉大学薬学部医薬品素材学講座

• 奥山 恵美

  千葉大学 院薬

• Satake M

  Institute Of Environmental Science For Human Life Ochanomizu University

• Satoh Y

  Faculty Of Pharmaceutical Sciences Chiba University

• Satoh Yoko

  Faculty Of Pharmaceutical Sciences Josai International University

• Yamazaki M

  School Of Pharmaceutical Sciences Kinki University

• SATAKE Motoyoshi

  National Institute of Health Sciences

• OKUYAMA Emi

  Faculty of Pharmaceutical Sciences, Chiba University

• YAMAZAKI Mikio

  Faculty of Pharmaceutical Sciences, Chiba University

• Satake Motoyoshi

  Division Of Pharmacognosy Phytochemistry And Narcotics National Institute Of Health Sciences

• FUJIMOTO Haruhiro

  Faculty of Pharmaceutical Sciences, Chiba University

• 藤本 治宏

  Chiba Univ. Chiba Jpn

• ISHIBASHI Masami

  Faculty of Pharmaceutical Sciences, Hokkaido University

• Ishibashi Masami

  Faculty Of Pharmaceutical Sciences Hokkaido University

• Satoh Yoko

  Faculty Of Pharmaceutical Sciences Chiba University

• Okuyama Emi

  Faculty Of Pharmaceutical Science Chiba University

• OKUYAMA Emi

  Laboratory of Pharmacognosy, Faculty of Pharmaceutical Sciences, Josai International University

• HOMMA Masayuki

  Faculty of Pharmaceutical Sciences, Chiba University

• GHAZALI Azizi

  Universiti Sains Malaysia

• Homma Masayuki

  Faculty Of Pharmaceutical Sciences Chiba University

• Ito Masaki

  The First Department Of Internal Medicine Mie University School Of Medicine

• Okuyama E

  Laboratory Of Pharmacognosy Faculty Of Pharmaceutical Sciences Josai International University

• Fujimoto Haruhiro

  Faculty Of Pharmaceutical Sciences Chiba University

• Ishibashi Masami

  Faculty Of Pharmaceutical Sciences Chiba University

• Yamazaki Mikio

  Faculty Of Pharmaceutical Sciences Chiba University

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