Analgesic Components of Saposhnikovia Root : Saposhnikovia divaricata

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概要

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• By activity-oriented separation using the writhing method in mice, the analgesic components of Saposhnikovia root(Saposhnikovia divaricata Schischkin; Umbelliferae)were identified to be chromones, coumarins, polyacetylenes and 1-acylglycerols. Two new components, divaricatol and(3'S)-hydroxydeltoin, were also isolated. The most potent analgesia was observed in chromones such as divaricatol, ledebouriellol and hamaudol, which inhibited writhing inhibition at an oral dose of 1 mg/kg in mice. Acylglycerols also showed inhibition significantly at a dose of 5 mg/kg. In some pharmacological tests using sec-O-glucosylhamaudol, the compound showed analgesia by the tail pressure and the Randall & Selitto methods, and its writhing inhibition was not reversed by naloxone.

• 公益社団法人日本薬学会の論文
• 2001-02-01

著者

• INAGAKI MASANORI

  Faculty of Pharmaceutical Sciences, Kyushu University

• 山崎 幹夫

  千葉大学薬学部

• 藤本 治宏

  千葉大院薬

• 山崎 幹夫

  千葉大学薬学部医薬品素材学講座

• 奥山 恵美

  千葉大学 院薬

• Yamazaki M

  School Of Pharmaceutical Sciences Kinki University

• OKUYAMA Emi

  Faculty of Pharmaceutical Sciences, Chiba University

• YAMAZAKI Mikio

  Faculty of Pharmaceutical Sciences, Chiba University

• HASEGAWA Tetsuya

  Faculty of Pharmaceutical Sciences, Josai University

• FUJIMOTO Haruhiro

  Faculty of Pharmaceutical Sciences, Chiba University

• 藤本 治宏

  Chiba Univ. Chiba Jpn

• ISHIBASHI Masami

  Faculty of Pharmaceutical Sciences, Hokkaido University

• Ishibashi Masami

  Faculty Of Pharmaceutical Sciences Hokkaido University

• Hasegawa Tetsuya

  Faculty Of Pharmaceutical Sciences Chiba University

• Okuyama Emi

  Faculty Of Pharmaceutical Science Chiba University

• MATSUSHITA Takamitsu

  Faculty of Pharmaceutical Sciences, Chiba University

• Matsushita T

  Faculty Of Pharmaceutical Sciences Chiba University

• OKUYAMA Emi

  Laboratory of Pharmacognosy, Faculty of Pharmaceutical Sciences, Josai International University

• Matsushita Takamitsu

  Faculty Of Pharmaceutical Sciences Chiba University

• Ito Masaki

  The First Department Of Internal Medicine Mie University School Of Medicine

• Okuyama E

  Laboratory Of Pharmacognosy Faculty Of Pharmaceutical Sciences Josai International University

• Fujimoto Haruhiro

  Faculty Of Pharmaceutical Sciences Chiba University

• Ishibashi Masami

  Faculty Of Pharmaceutical Sciences Chiba University

• Yamazaki Mikio

  Faculty Of Pharmaceutical Sciences Chiba University

• Hasegawa Tetsuya

  Faculty Of Pharmaceutical Science Josai International University

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