1,3-Dimethylisoguaninium, an Antiangiogenic Purine Analog from the Sponge Amphimedon paraviridis

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概要

• 論文の詳細を見る

• An antiangiogenic purine analog, 1,3-dimethylisoguaninium (1), was isolated from the ethanol (EtOH) extract of the Okinawan sponge Amphimedon paraviridis. The structure was elucidated on the basis of its spectral properties and X-ray crystallographic analysis. Compound 1 exhibited specific inhibition of the basic fibroblast growth factor (bFGF)-induced proliferation of bovine aorta endothelial cells (BAECs). Moreover, compound1 reduced the tube formation of BAECs in a time-dependent manner.

• 公益社団法人日本薬学会の論文
• 2003-06-01

著者

• INAGAKI MASANORI

  Faculty of Pharmaceutical Sciences, Kyushu University

• Ono Mayumi

  Department Of Pharmaceutical Oncology Graduate School Of Pharmaceutical Sciences Kyushu University

• Ono M

  Departments Of Biochemistry Kyushu University School Of Medicine

• KUWANO Michihiko

  Research Center of Innovative Cancer Therapy, Kurume University School of Medicine

• Ono Mayumi

  Graduate School Of Medical Sciences Kyushu University

• MIYAMOTO Tomofumi

  Graduate School of Pharmaceutical Sciences, Kyushu University

• HIGUCHI Ryuichi

  Graduate School of Pharmaceutical Sciences, Kyushu University

• Jeong Sei-joon

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Jeong Sei-joon

  九州大学 薬研究院

• Kuwano Michihiko

  九州大学 医学研究院形態機能病理学

• Kuwano M

  Research Center For Innovate Cancer Therapy Kurume University

• Kuwano M

  Departments Of Biochemistry Kyushu University School Of Medicine

• Ono Mayumi

  Graduate School Of Arts And Sciences University Of Tokyo

• Soest W.m.van

  Institute For Biodiversity And Ecosystem Dynamics University Of Amsterdam

• Ono M

  Analytical Laboratory Self-medication Laboratories Taisho Pharmaceutical Co. Ltd.

• Miyamoto Tomofumi

  Graduate School Of Pharmaceutical Sciences Kyushu Univ.

• KUWANO Michihiko

  Graduate School of Medical Sciences, Kyushu University

• INAGAKI Masanori

  Graduate School of Pharmaceutical Sciences, Kyushu University

• Kuwano M

  Innovative Anticancer Diagnosis And Therapeutics Innovation Center For Medical Redox Navigation Kyus

• Kuwano Michihiko

  Research Center For Innovative Cancer Therapy Kurume University

• Kuwano Michihiko

  Graduate School Of Medical Sciences Kyushu University

• Higuchi Ryuichi

  Graduate School Of Pharmaceutical Sciences Kyushu Univ.

• Ono Masaki

  Analytical Laboratory Self-medication Laboratories Taisho Pharmaceutical Co. Ltd.

• Ono M

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Inagaki Masanori

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Maruta Tomoki

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Ito Masaki

  The First Department Of Internal Medicine Mie University School Of Medicine

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