Immunomodulatory Constituents from an Ascomycete, Microascus tardifaciens
スポンサーリンク
概要
- 論文の詳細を見る
Fractionation guided by the immunosuppressive activity of the defatted AcOEt extract of an Ascomycete, Microascus tardifaciens, afforded eight constituents, questin (emodin 8-O-methylether) (1), rubrocristin (2), 5,7-dihydroxy-4-methylphthalide (3), cladosporin (asperentin) (4), cladosporin 8-O-methylether (5), tardioxopiperazine A [cyclo-L-alanyl-5-isopentenyl-2-(1', 1'-dimethylallyl)-L-tryptophan] (6), tardioxopiperazine B [cyclo-L-alanyl-7-isopentenyl-2-(1', 1'-dimethylallyl)-L-tryptophan] (7), and asperflavin (8), among which 6 and 7 were new compounds. Compounds 1 and 2 showed considerably high immunosuppressive activity, 6 was moderate and, 3,4,5,7 and 8 showed low activity.
- 公益社団法人日本薬学会の論文
- 1999-10-15
著者
-
山崎 幹夫
千葉大学薬学部
-
藤本 治宏
千葉大院薬
-
山崎 幹夫
千葉大学薬学部医薬品素材学講座
-
奥山 恵美
千葉大学 院薬
-
Yamazaki M
School Of Pharmaceutical Sciences Kinki University
-
OKUYAMA Emi
Faculty of Pharmaceutical Sciences, Chiba University
-
YAMAZAKI Mikio
Faculty of Pharmaceutical Sciences, Chiba University
-
FUJIMOTO Haruhiro
Faculty of Pharmaceutical Sciences, Chiba University
-
藤本 治宏
Chiba Univ. Chiba Jpn
-
Okuyama Emi
Faculty Of Pharmaceutical Science Chiba University
-
OKUYAMA Emi
Laboratory of Pharmacognosy, Faculty of Pharmaceutical Sciences, Josai International University
-
FUJIMAKI Toshiyuki
Faculty of Pharmaceutical Sciences, Chiba University
-
Okuyama E
Laboratory Of Pharmacognosy Faculty Of Pharmaceutical Sciences Josai International University
-
Fujimoto Haruhiro
Faculty Of Pharmaceutical Sciences Chiba University
-
Yamazaki Mikio
Faculty Of Pharmaceutical Sciences Chiba University
-
Fujimaki T
Faculty Of Pharmaceutical Sciences Chiba University
関連論文
- Brazilian Natural Medicines. III. Structures of Triterpene Oligoglycosides and Lipase Inhibitors from Mate, Leaves of Ilex paraguariensis
- Medicinal Flowers. XXVI. Structures of Acylated Oleanane-Type Triterpene Oligoglycosides, Yuchasaponins A, B, C, and D, from the Flower Buds of Camellia oleifera : Gastroprotective, Aldose Reductase Inhibitory, and Radical Scavenging Effects
- Medicinal Flowers. XXI. : Structures of Perennisaponins A, B, C, D, E, and F, Acylated Oleanane-Type Triterpene Oligoglycosides, from the Flowers of Bellis perennis
- Medicinal Flowers. XXVII : New Flavanone and Chalcone Glycosides, Arenariumosides I, II, III, and IV, and Tumor Necrosis Factor-α Inhibitors from Everlasting, Flowers of Helichrysum arenarium
- Structures of Acetylated Oleanane-Type Triterpene Saponins, Rarasaponins IV, V, and VI, and Anti-hyperlipidemic Constituents from the Pericarps of Sapindus rarak
- Absolute Stereostructures of Olibanumols A, B, C, H, I, and J from Olibanum, Gum-Resin of Boswellia carterii, and Inhibitors of Nitric Oxide Production in Lipopolysaccharide-Activated Mouse Peritoneal Macrophages
- Medicinal Flowers. XXIV. Chemical Structures and Hepatoprotective Effects of Constituents from Flowers of Hedychium coronarium
- Medicinal Flowers. XXIII. New Taraxastane-Type Triterpene, Punicanolic Acid, with Tumor Necrosis Factor-α Inhibitory Activity from the Flowers of Punica granatum
- Bioactive Constituents from Chinese Natural Medicines. XXXII : Aminopeptidase N and Aldose Reductase Inhibitors from Sinocrassula indica: Structures of Sinocrassosides B_4, B_5, C_1, and D_1-D_3
- Medicinal Foodstuffs. XXXIV. : Structures of New Prenylchalcones and Prenylflavanones with TNF-α and Aminopeptidase N Inhibitory Activities from Boesenbergia rotunda
- Medicinal foodstuffs (33) Gastroprotective principles from Boesenbergia rotunda (zingiberaceae): absolute stereostructures of diels-alder type addition prenylchalcones
- Bioactive Constituents from Chinese Natural Medicines. XXVI : Chemical Structures and Hepatoprotective Effects of Constituents from Roots of Rhodiola sachalinensis
- Bioactive Constituents from Chinese Natural Medicines. XXIV. : Hypoglycemic Effects of Sinocrassula indica in Sugar-Loaded Rats and Genetically Diabetic KK-A^y Mice and Structures of New Acylated Flavonol Glycosides, Sinocrassosides A_1, A_2, B_1, and B_2
- クサウラベニタケの毒性成分の研究(第2報) : 溶血素の精製と溶血条件の検討
- クサウラベニタケの毒性成分の研究(第1報)生物活性と毒性成分の探索
- ファルマシアレビュー : 13年を振り返って
- Apoptosis-Inducing Effects of Sterols from the Dried Powder of Cultured Mycelium of Cordyceps sinensis
- A-33 ヒト肝ミクロゾームの薬物代謝能におよぼす Notopterol の影響
- インドネシア産生薬の薬理活性成分に関する研究(第3報)Brucea javanica(L.)MERR.の毒性成分
- インドネシア産生薬の抗拘束水浸ストレス潰瘍活性成分の研究(第1報)Artocarpus integra MERR.(ヒメハラミツ)から(±)-Catechinの単離と同定
- Bioactive Constituents from Chinese Natural Medicines. XXIII. Absolute Structures of New Megastigmane Glycosides, Sedumosides A_4, A_5, A_6, H, and I, and Hepatoprotective Megastigmanes from Sedum sarmentosum
- Bioactive Constituents from Chinese Natural Medicines. XXII. Absolute Structures of New Megastigmane Glycosides, Sedumosides E_1, E_2, E_3, F_1, F_2, and G, from Sedum sarmentosum (Crassulaceae)
- Bioactive Saponins and Glycosides. XXVIII. New Triterpene Saponins, Foliatheasaponins I, II, III, IV, and V, from Tencha (the Leaves of Camellia sinensis)
- P-469 ANTI-ALLERGIC AND ANTI-INFLAMMATORY ACTIVITIES OF 1'S-1'-ACETOXYCHAVICOL ACETATE AND RELATED COMPOUNDS
- P-466 ACYLATED PHENETHYLGLYCOSIDES WITH VASORELAXANT ACTIVITY FROM CISTANCHE TUBULOSA
- P-298 SYNTHESIS OF 1,5-ANHYDRO-5-AZA-D-GLUCITOL ANALOGS OF SALACINOL AND THEIR α-GLUCOSIDASE INHIBITORY ACTIVITIES
- Monoterpene Constituents from Cistanche tubulosa : Chemical Structures of Kankanosides A-E and Kankanol
- Inhibitors of Nitric Oxide Production from the Rhizomes of Alpinia galanga : Structures of New 8-9' Linked Neolignans and Sesquineolignan
- Antidiabetogenic constituents from Salacia species(Chemical & Pharmacological study)
- Bioactive Saponins and Glycosides. XI. Structures of New Dammarane-Type Triterpene Oligoglycosides, Quinquenosides I, II, III, IV, and V, from American Ginseng, the Roots of Panax quinquefolium L.
- Bioactive Saponins and Glycosides. IX. Notoginseng (2) : Structures of Five New Dammarane-Type Triterpene Oligoglycosides, Notoginsenosides-E, -G, -H, -I, and -J, and a Novel Acetylenic Fatty Acid Glycoside, Notoginsenic Acid β-Sophoroside, from the Dried
- Bioactive Saponins and Glycosides. VIII. Notoginseng (1) : New Dammarane-Type Triterpene Oligoglycosides, Notoginsenosides-A, -B, -C, and -D, from the Dried Root of Panax notoginseng (BURK.) F. H. CHEN
- Medicinal Foodstuffs. VII. On the Saponin Constituents with Glucose and Alcohol Absorption-Inhibitory Activity from a Food Garnish "Tonburi", the Fruit of Japanese Kochia scoparia (L.) SCHRAD. : Structures of Scoparianosides A, B, and C
- Studies on Kochiae Fructus. II. On the Saponin Constituents from the Fruit of Chinese Kochia scoparia (Chenopodiaceae) : Chemical Structures of Kochianosides I, II, III, and IV
- NOVEL iNDOLE S, O-BISDESMOSIDE, CALANTHOSIDE, THE PRECURSOR GLYCOSIDE OF TRYPTANTHRIN, INDIRUBIN, AND ISATIN, WITH INCREASING SKIN BLOOD FLOW PROMOTING EFFECTS, FROM TWO CALANTHE SPECIES (ORCHIDACEAE)
- Medicinal Foodstuffs. XIV. On the Bioactive Constituents of Moroheiya. (2) : New Fatty Acids, Corchorifatty Acids A, B, C, D, E, and F, from the Leaves of Corchorus olitorius L. (Tiliaceae) : Structures and Inhibitory Effect on NO Production in Mouse Peri
- Antidiabetic Principles of Natural Medicines. II. Aldose Reductase and α-Glucosidase Inhibitors from Brazilian Natural Medicine, the Leaves of Myrcia multiflora DC. (Myrtacae) : Structures of Myrciacitrins I and II and Myrciaphenones A and B
- Bioactive Constituents of Chinese Natural Medicines. IV. Rhodiolae Radix. (2). : On the Histamine Release Inhibitors from the Underground Part of Rhodiola sacra (PRAIN ex HAMET) S. H. Fu (Crassulaceae) : Chemical Structures of Rhodiocyanoside D and Sacran
- Medicinal Foodstuffs. VI. Histamine Release Inhibitors from Kidney Bean, the Seeds of Phaseolus vulgaris L : Chemical Structures of Sandosaponins A and B
- Medicinal Foodstuffs. V. Moroheiya. (1) : Absolute Stereostructures of Corchoionosides A, B, and C, Histamine Release Inhibitors from the Leaves of Vietnamese Corchorus olitorius L. (Tiliaceae)
- Bioactive Constituents of Chinese Natural Medicines. II. Rhodiolae Radix. (1). Chemical Structures and Antiallergic Activity of Rhodiocyanosides A and B from the Underground Part of Rhodiola guadrifida (PALL.) FISCH. et MEY. (Crassulaceae)
- 6 麻薬 : 陶酔のかげのおとし穴(授業に役立つ薬のはなし)
- REGIOSELECTIVE OXIDATION OF THE HYDROXYL GROUP IN POLYHYDROXYLATED TRITERPENES BY THE INDIRECT ANODIC OXIDATION METHOD
- Melanogenesis Stimulation in Murine B16 Melanoma Cells by Umberiferae Plant Extracts and Their Coumarin Constituents(Pharmacognosy)
- P-328 MOLECULAR CLONING AND CHARACTERIZATION OF BITTER-SPECIFIC GENES FROM LUPINUS ANGUSTIFOLIUS
- Bioactive Constituents from Chinese Natural Medicines. XIV. New Glycosides of β-Carboline-Type Alkaloid, Neolignan, and Phenylpropanoid from Stellaria dichotoma L. var. lanceolata and Their Antiallergic Activities
- Medicinal Flowers. VI. : Absolute Stereostructures of Two New Flavanone Glycosides and a Phenylbutanoid Glycoside from the Flowers of Chrysanthemum indicum L. : Their Inhibitory Activities for Rat Lens Aldose Reductase
- 毒・薬・トキシコロジー
- Indonesian Medicinal Plants. XIX. Chemical Structures of Four Additional Resin-Glycosides, Mammosides A, B, H_1,and H_2,from the Tuber of Merremia mammosa (Convolvulaceae)
- Inhibitory Effects of Thunberginols A, B, and F on Degranulations and Releases of TNF-α and IL-4 in RBL-2H3 Cells(Pharmacognosy)
- いま, なぜ医薬分業なのか(私にとって医薬分業とは)
- 5 麻酔薬 : 手術の革命を支えた薬(授業に役立つ薬のはなし)
- ルーツへの回帰
- アルカロイドの化学(身近にある天然物のはなし)
- 小さな研究の歴史 : 生物活性の追跡
- 日本薬学会学術賞受賞 北川勲氏の業績
- The 6th Asian Symposium on Medicinal Plants and Spices(ASOMPS)
- 阿片(あへん)の道
- モノアミン酸化酵素阻害活性を有するトロポロン関連化合物について
- 毒はなぜ毒なのか : 毒と中毒のサイエンス
- 北川晴雄先生を偲んで
- 薬学研究の未来像(21世紀へ向けての薬学の創造)
- 子嚢菌 Sordaria gondaensis の免疫抑制活性成分
- P-41 防風の鎮痛活性成分 II.
- 72(P47) Gelasinospora属子嚢菌3種からの免疫調節活性成分(ポスター発表の部)
- A New Series of Coumarin Derivatives Having Monoamine Oxidase Inhibitory Activity from Monascus anka
- Sesquiterpenes from Curcuma comosa
- Structures of New Sesquiterpenes from Curcuma comosa
- 子嚢菌 Emericella corrugata からの新毒性代謝産物
- Melanogenesis Stimulation in Murine B16 Melanoma Cells by Piper nigrum Leaf Extract and Its Lignan Constituents(Pharmacognosy)
- Anti-androgenic and Hair Growth Promoting Activities of Lygodii Spora (Spore of Lygodium japonicum)I. : Active Constituents Inhibiting Testosterone 5α-Reductase
- 薬学会館物語
- 61(P31) 子嚢菌Diplogelasinospora grovesii及び関連菌からの新免疫抑制活性成分(ポスター発表の部)
- Antidiabetic Principles of Natural Medicines. III. Structure-Related Inhibitory Activity and Action Mode of Oleanolic Acid Glycosides on Hypoglycemic Activity
- Protective Activity of Geranium Oil and Its Component, Geraniol, in Combination with Vaginal Washing against Vaginal Candidiasis in Mice(Microbiology)
- Four New Immunosuppressive Components, Kobiin and Kobifuranones A, B, and C, from an Ascomycete, Gelasinospora kobi
- 子のう菌 Talaromyces luteus より得られた新MAO阻害物質 Luteusin A と可逆的MAO-B阻害薬Ro16-6491との ex vivo におけるMAO阻害活性の比較検討
- 子嚢菌 Gelasinospora pseudoreticulata 由来 Mycelia Sterilia からのモノアミン酸化酵素阻害活性成分
- Anti-Candida Activity of Calprotectin in Combination with Neutrophils or Lactoferrin
- Kinetical Analysis of Tumor Cell Death-Inducing Mechanism by Polymorphonuclear Leukocyte-Derived Calprotectin: Involvement of Protein Synthesis and Generation of Reactive Oxygen Species in Target Cells
- Structures of New Friedelane-and Norfriedelane-Type Triterpenes and Polyacylated Eudesmane-Type Sesquiterpene from Salacia chinensis LINN. (S. prinoides DC., Hippocrateaceae) and Radical Scavenging Activities of Principal Constituents
- 医薬品適正使用推進方策検討委員会中間報告について
- ファルマシア25年
- A Hydroxyl Group of Flavonoids Affects Oral Anti-inflammatory Activity and Inhibition of Systemic Tumor Necrosis Factor-α Production
- Inhibitory Effect of Perilla Leaf Extract and Luteolin on Mouse Skin Tumor Promotion
- Luteolin as an Anti-inflammatory and Anti-allergic Constituent of Perilla frutescens
- Detection of Genipin/Geniposide-Target Molecules by a Geniposide Overlay Method Using Anti-Geniposide Antibody
- Neuritogenesis of Herbal (+)- and (-)-Syringaresinols Separated by Chiral HPLC in PC12h and Neuro2a Cells
- Molecular Characterization of a Novel Quinolizidine Alkaloid O-Tigloyltransferase : cDNA Cloning, Catalytic Activity of Recombinant Protein and Expression Analysis in Lupinus Plants
- Chemical Constituents from Seeds of Panax ginseng : Structure of New Dammarane-Type Triterpene Ketone, Panaxadione, and HPLC Comparisons of Seeds and Flesh
- Bioactive Constituents from Chinese Natural Medicines. XXXIII : Inhibitors from the Seeds of Psoralea corylifolia on Production of Nitric Oxide in Lipopolysaccharide-Activated Macrophages(Pharmacognosy)
- Medicinal flowers (25) Structures of floratheasaponin J and chakanoside 2 from Japanese tea flower, flower buds of Camellia sinensis
- Structures of New Monoterpenes from Thai Herbal Medicine Curcuma comosa
- Medicinal Flowers. XXII Structures of Chakasaponins V and VI, Chakanoside I, and Chakaflavonoside A from Flower Buds of Chinese Tea Plant (Camellia sinensis)
- Synthesis of 3-Substituted Isocoumarins and Their Inhibitory Effects on Degranulation of RBL-2H3 Cells Induced by Antigen
- New Triterpene Constituents, Foliasalacins A_1-A_4, B_1-B_3, and C, from the Leaves of Salacia chinensis
- Absolute Structures of New Megastigmane Glycosides, Foliasalaciosides E_1, E_2, E_3, F, G, H, and I from the Leaves of Salacia chinensis
- Structures of New Acylated Oleanene-Type triterpene Oligoglycosides, Theasaponins E_1 and E_2. from the Seeds of Tea Plant, Camellia sinensis (L.) O. KUNTZE
- Reinvestigation of Absolute Stereostructure of (-)-Rosiridol : Structures of Monoterpene Glycosides, Rosiridin, Rosiridosides A, B, and C, from Rhodiola sachalinensis
- Bioactive Constituents from Chinese Natural Medicines. XXIX. : Monoterpene and Monoterpene Glycosides from the Roots of Rhodiola sachalinensis