Nine Constituents Including Six Xanthone-Related Compounds Isolated from Two Ascomycetes, Gelasinospora santi-florii and Emericella quadrilineata, Found in a Screening Study Focused on Immunomodulatory Activity

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Five metabolites tentatively called GS-1 (1)-5 (5) from Gelasinospora santi-florii, and four tentatively called EQ-4 (6), EQ-6 (7)-8 (9) together with 1-4 from Emericella quadrilineata have been isolated in a screening study on immunomodulatory fungal constituents. Among these nine metabolites, EQ-7 and 8 have been unknown. This time, the structures of GS-4 which has previously been isolated, EQ-7, and -8 have been determined to be (4R, 4aS, 9aR)-1, 9a-dihydronidulalin A (4), (4S, 4aR, 9aR)-4a-carbomethoxy-1, 4, 4a, 9a-tetrahydro-4, 8-dihydroxy-6-methylxanthone (8), and 9-hydroxymicroperfuranone (9), respectively, and the six other metabolites have been identified. On bioassay, a dihydroxanthone, nidulalin A (1), a hexaketide, sordarial (5), and a xanthone, pinselin (7) have displayed significant immunosuppressive activities. The structure-activity relationships of these constituents have also been discussed.
公益社団法人日本薬学会の論文
2006-04-01