Fast Atom Bombardment Tandem Mass Spectrometry of Benzyloxycarbonyl-Protected Tetrapeptide Derivatives Containing Proline
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概要
- 論文の詳細を見る
Fragmentations of N-benzyloxycarbonyl-protected tetrapeptide ethyl esters containing L-proline and L-alanine in the gas phase were examined by the collisional-activated decomposition of the deprotonated molecule and the fragment ions produced by the cleavage of the tetrapeptide derivatives, in which changes in both the number and positions of the prolyl residues were observed, in negative-ion FAB-MS. The cleavage patterns of these ions in the collisional-activated decomposition mass spectra were observed to depend on the number and positions of prolyl residues in the peptide derivatives. These results indicate that the conformational difference in the tetrapeptide derivatives due to the existence of L-proline may be an important factor responsible for the fragmentations of peptide molecules in the gas phase.
- 公益社団法人日本薬学会の論文
- 1996-10-15
著者
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ISOBE Ryuichi
Faculty of Pharmaceutical Sciences, Kyushu University
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Isobe R
Department Of Medical Electronics Engineering Faculty Of Engineering Towa University
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Isobe Ryuichi
Tohwa University
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Isobe Ryuichi
Faculty Of Pharmaceutical Sciences Kyushu University
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Yamamoto Megumi
School Of Agriculture Kyushu Tokai University
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YAMAMOTO MAGOBEI
Faculty of Pharmaceutical Sciences, Fukuoka University
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Isobe R
Faculty Of Pharmaceutical Sciences Kyushu University
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TSUNEMATSU Hideaki
Faculty of Pharmaceutical Sciences, Fukuoka University
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FUTATSUKA Yoshihito
Faculty of Pharmaceutical Sciences, Fukuoka University
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Yamamoto Magobei
Faculty Of Pharmaceutical Sciences Fukuoka University
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Tsunematsu H
Faculty Of Pharmaceutical Sciences Fukuoka University
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Futatsuka Yoshihito
Faculty Of Pharmaceutical Sciences Fukuoka University
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