Synthesis and Antimicrobial Characteristics of Novel Biocides, 4,4'-(1,6-Hexamethylenedioxydicarbonyl)bis(1-alkylpyridinium iodide)s

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概要

• 論文の詳細を見る

• Potent new biocides against both bacteria and fungi, 4,4'-(1,6-hexamethylenedioxydicarbonyl)bis(1-alkylpyridinium iodide)s (4DOCBP-6,n) (alkyl chain length, n=8,10,12,14,16 and 18) were synthesized. 4DOCBP-6,n is bis-quaternary ammonium compound (bis-QAC) and has a symmetrical dimeric structure which is composed of two alkylpyridinium iodides connected with a hexamethylenedioxydicarbonyl chain. 4DOCBP-6,10 and 4DOCBP-6,12 exhibited wide and effective antimicrobial spectra, compared with those of typical bactericides, N-dodecylpyridinium iodides (P-12) and benzyldimethyldodecylammonium chloride (BAC), or a popularly-used fungicide, 2-(4-thiazolyl)benzimidazole (TBZ). Their superior properties would be due to the unique dimeric structure which contains two active moieties in a molecule.

• 公益社団法人日本薬学会の論文
• 1999-07-15

著者

• MAEDA Takuya

  Department of Tropical Medicine and Parasitology, School of Medicine, Keio University

• Maeda Takuya

  Department Of Biotechnology Faculty Of Eigineering Osaka University

• Maeda Takuya

  Department Of Biological Science And Technology Faculty Of Engineering The University Of Tokushima

• Ohkura Kazuto

  Department Of Biological Science And Technology Faculty Of Engineering The University Of Tokushima

• Ohkura Kazuto

  Department Of Applied Biological Sciences School Of Agricultural Sciences Nagoya University

• Yamamoto Megumi

  School Of Agriculture Kyushu Tokai University

• Yoshida Munehiro

  Takamatsu Works Inui Corporation

• Ohno Kosei

  Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido

• Yoshida M

  Takamatsu Works Inui Corporation

• NAGAMUNE Hideaki

  Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima

• KOURAI Hiroki

  Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima

• OKAZAKI KIYO

  Faculty of Human Life Science, Shikoku University

• MANABE YUKI

  New Materials Research Institute, Otsuka Pharmaceutical Factory Inc

• YAMAMOTO Masashi

  Biochemical Laboratory, Saraya Co., Ltd.,

• Okazaki K

  Faculty Of Human Life Science Shikoku University

• Kourai Hiroki

  Department Of Biological Science And Technology Faculty Of Engineering The University Of Tokushima

• Manabe Y

  Department Of Oral Microbiology School Of Dentistry The University Of Tokushima

• Nagamune Hideaki

  Department Of Biological Science And Technology Faculty Of Engineering The University Of Tokushima

• Maeda Takuya

  Department of Agricultural Chemistry, University of Osaka Prefecture

• Kourai Hiroki

  Department of Applied Chemistry, Technical College of Tokushima University

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