Production of S-(+)-Ibuprofen with High Optical Purity from a Nitrile Compound by Cells immobilized on Cellulose Porous Beads
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概要
- 論文の詳細を見る
The production of S-(+)-ibuprotein (S-IP)from a nitrile compound by immobilized cells was investigated. Cells immobilized within both κ-carrageenan and Ca-alginate showed a lower reaction conversion and gave a product of lower optical purity than free, intact cells. However the reaction of cells immobilized in cellulose porous beads(CPBs)with pore sizes of 10-30μm and an average diameter of 200 μm resulted in a yield and optical purity as high as those given by intact cells. Even when the CPBs were used repeatedly up to 12 times, an S-IP optical purity of more than 99% was maintained, but the reaction conversion decreased from 48% to 32%.
- 社団法人日本生物工学会の論文
- 1994-08-25
著者
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TAKAGI Mutsumi
International Center for Biotechnology, Osaka University
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Takagi Mutsumi
Pharmaceutical Research And Development Department Asahi Chemical Industry Company Ltd.:(present Add
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FUJIMATSU ISAO
Pharmaceutical Research and Development Department, Asahi Chemical Industry Company Ltd.
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SHIROKAZE JUNICHI
Cellulose Fiber Development Department, Asahi Chemical Industry Company Ltd.,
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OISHI KAZUHIKO
PhaRmaceutical Research and Development Department, Asahi Chemical Industry Company Ltd.,
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OTSUBO KAZUMASA
Pharmaceutical Research and Development Department, Asahi Chemical Industry Company Ltd.,
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YAMAMOTO KEIZOU
Pharmaceutical Research and Development, Asahi Chemical Industry Company Ltd.,
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YOSHIDA NOBUYUKI
Pharmaceutical Research and Development Department, Asahi Chemical Industry Company Ltd.,
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Fujimatsu I
Asahi Chemical Ind. Co. Ltd. Miyazaki Jpn
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Oishi Kazuhiko
Pharmaceutical Research And Development Department Asahi Chemical Industry Company Ltd.
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Takagi M
Asahi Chemical Industry Co. Ltd. Shizuoka Jpn
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Maeda Takuya
Department Of Biotechnology Faculty Of Eigineering Osaka University
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Otsubo Kazumasa
Pharmaceutical Research And Development Department Asahi Chemical Industry Company Ltd.
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Shirokaze Junichi
Cellulose Fiber Development Department Asahi Chemical Industry Company Ltd.
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Fujimatsu Isao
Pharmaceutical Research And Development Department Asahi Chemical Industry Co. Ltd.
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Takagi M
Japan Advanced Inst. Sci. And Technol. Ishikawa Jpn
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Oishi K
Nihon Univ. Kanagawa Jpn
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Yamamoto Keizou
Pharmaceutical Department Asahi Chemical Industry Co. Ltd.
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Yamamoto Keizou
Pharmaceutical Research And Development Asahi Chemical Industry Company Ltd.
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Yoshida Nobuyuki
Pharmaceutical Research And Development Department Asahi Chemical Industry Company Ltd.
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