Effect of Static Pressure on Human Granulocyte-Macrophage Stimulating Factor (hGM-CSF) Production by Chinese Hamster Ovary Cells

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概要

• 論文の詳細を見る

• The effect of static pressure on the production of human granulocyte-macrophage colony stimulating factor (hGM-CSF) by the Chinese hamster ovary (CHO) cell line DR1000L4N was investigated. Although constant static pressures between 0.15 and 0.9 MPa had little influence on specific growth rate, the specific production rate of hGM-CSF increased from 1.23 to 1.62 × 10^<-13> mg/cell/h in proportion to static pressure. The specific rate of tPA production by the human embryo lung cell line MRC-5 also increased from 2.92 to 6.38 × 10^<-12> mg/cell/h as static pressure increased. The expression level of hGM-CSF mRNA increased with the pressurization even for 4 h.

• 社団法人日本生物工学会の論文
• 2002-09-25

著者

• TAKAGI Mutsumi

  International Center for Biotechnology, Osaka University

• YOSHIDA Toshiomi

  International Center for Biotechnology, Osaka University

• Yoshida Toshiomi

  大阪大学生物工学国際交流センター

• Yoshida T

  International Center For Biotechnology Osaka University

• Yoshida Toshiomi

  International Center For Biotechnology Osaka University

• 吉田 豊和

  岐阜大・工・生命工

• Takagi Mutsumi

  International Center For Biotechnology Osaka University:(present Address)division Of Biotechnology A

• Takagi M

  International Center For Biotechnology Osaka University

• Takagi M

  Japan Advanced Inst. Of Sci. And Technol. Ishikawa Jpn

• Takagi M

  Osaka Univ. Osaka Jpn

• GONG HENG

  International Center for Biotechnology, Osaka University

• MORIYAMA TETSUHIRO

  International Center for Biotechnology, Osaka University

• OHNO TSUYOSHI

  International Center for Biotechnology, Osaka University

• Gong Heng

  International Center For Biotechnology Osaka University

• Ohno Tsuyoshi

  International Center For Biotechnology Osaka University

• Yoshida T

  Kinki Univ. Nara Jpn

• Moriyama Tetsuhiro

  International Center For Biotechnology Osaka University

• Takagi Mutsumi

  Internatioal Center For Biotechnology Osaka University

• Takagi Mutsumi

  School Of Materials Science Japan Advanced Institute Of Science And Technology

• Yoshida Toshiomi

  Internatioal Center For Biotechnology Osaka University

• 吉田 豊和

  岐阜大 工

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