HIV-1 Reverse Transcriptase-Inhibitory Compound in Salvia officinalis
スポンサーリンク
概要
- 論文の詳細を見る
Methanol extracts of 98 specimens of the family Labiatae were assayed for their HIV-1 revers transcriptaseinhibitory activity. Potent activity was found in the genera Salvia and Glechoma. The major inhibitory compound in S. officinalis was identified as oleanolic acid, a pentacyclic triterpenoid, by means of 1H-NMR, 13C-NMR, and EI-MS. This compound showed an IC50 value of 1.6-2.0 μg/ml, similar to the authentic oleanolic acid preparation. Oleanolic acid was not a common component of the genus Salvia and not the sole inhibitory compound in Salvia.
- 社団法人 日本食品科学工学会の論文
- 2000-08-01
著者
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Oishi Kazuhiko
Pharmaceutical Research And Development Department Asahi Chemical Industry Company Ltd.
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WATANABE Masahito
Department of Physics, Gakusyuin University
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KATO Jun
Department of Gastroenterology, University of Tokyo
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Oishi K
Nihon Univ. Kanagawa Jpn
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Ogihara J
Nihon Univ. Kanagawa Jpn
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Ogihara Jun
Department Of Agricultural And Biological Chemistry College Of Bioresource Sciences Nihon University
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Oishi Kunio
Department Of Agricultural Biological Chemistry College Of Bioresource Sciences Nihon University
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Kobayashi Yasuko
Department Of Pediatrics Tohoku University School Of Medicine
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Kato J
Ntt Corp. Musashino‐shi Jpn
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Watanabe Masahito
Department Of Anatomy And Cell Biology Osaka Medical College
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Kato Jun
Department Of Gastroenterology And Hepatology Okayama University Graduate School Of Medicine Dentist
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Kobayashi Yasuko
Department Of Agricultural And Biological Chemistry College Of Bioresource Sciences Nihon University
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Watanabe M
Department Of Agricultural And Biological Chemistry College Of Bioresource Sciences Nihon University
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Kato Jun
Department Of Agricultural And Biological Chemistry College Of Bioresource Sciences Nihon University
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WATANABE Masahito
Department of Agricultural and Biological Chemistry, College of Bioresource Sciences, Nihon University
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