Localization of GABA, GAD65 and GAD67 in Rat Epiphyseal Growth Plate Chondrocytes
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概要
- 論文の詳細を見る
The distribution of γ-aminobutyrate (GABA) and its synthesizing enzyme glutamate decarboxylase (GAD) in the epiphyseal growth plate of the rat longbone was studied by immunohistochemistry. GABA, GAD65 and GAD67 immunoreactive chondrocytes were found inhypertrophic zones of the growth plate, but not in reserve and proliferative zones. In the hypertrophic zone, GABA immunoreactivity was more intense in the maturation zone than in the degeneralive zone and the zone of provisional calcification. Patterns of immunoreactivity for GAD65 and GAD67 were almost comparable to those of GABA. In addition, GAD65 and GAD67 mRNAs were detected by reverse transcriptase-polymerase chain reaction (RT-PCR). These results suggest that GABA, which is synthesized de novo in chondrocytes of the growth plate may have certain functional roles in skeletal growth.
- 日本組織細胞化学会の論文
著者
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WATANABE Masahito
Department of Physics, Gakusyuin University
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Watanabe M
Department Of Anatomy Osaka Medical College
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KANBARA KIYOTO
Department of Anatomy, Osaka Medical College
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Kanbara K
Department Of Anatomy Osaka Medical College
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Kanbara Kiyoto
Department Of Anatomy Osaka Medical College
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Tamayama Takumi
Department of Anatomy, Osaka Medical College
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Maemura Kentaro
Department of Anatomy, Osaka Medical College
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Kuno Masato
Department of Anatomy, Osaka Medical College
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Maemura Kentaro
Department Of Anatomy And Cell Biology Osaka Medical College
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Kuno Masato
Department Of Anatomy Osaka Medical College
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Tamayama Takumi
Department Of Anatomy Osaka Medical College
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Watanabe Masahito
Department Of Anatomy And Cell Biology Osaka Medical College
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WATANABE Masahito
Department of Agricultural and Biological Chemistry, College of Bioresource Sciences, Nihon University
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