CARBOHYDRATE DISTRIBUTION IN MAMMAL; WHOLE-BODY AUTORADIOGRAPHIC APPROACH

概要

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The development of new techniques has permitted new scientific assaults on the understanding of living bodies. The application and .combination of both classical and modern techniques offer new ideas for several kinds of research. The technique of whole-body auto radiography, which was first introduced in 1954 by Seven Ullberg, has been employed to examine the distribution of drugs and other chemicals within the animal body. This technique makes it possible to examine and compare the radioactivities of many organs and tissues under identical conditions. For over a decade, the distribution of labelled sugars in the mammalian body and the uptake of their metabolites by the tissues and organs have been studied in our laboratory. This article will focus on the whole-body autoradiographic studies of this area. As we have been trying to develop techniques of whole-body sectioning for histological and histochemical analysis for the purpose of confirming and extending the information obtained from whole-body autoradiographs, these techniques are also reviewed. Several applications of the whole-body sections will be discussed, and an idea concerning the metabolic cooperation of tissues and organs in the whole-body will be proposed.
日本組織細胞化学会の論文