DISTRIBUTION OF N-ACETYL [4,5,6,7,8,9-^<14>C] NEURAMINIC ACID IN MICE STUDIED BY WHOLE-BODY AUTORADIOGRAPHY

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The distribution of N-acetyl [4, 5, 6, 7, 8, 9-^<14>C] neuraminic acid ([^<14>C]-NeuNAc) was investigated by whole-body autoradiography. At 5 min after intravenous injection of [^<14>C] NeuNAc, high radioactivity was found in certain tissues and organs such as the blood, kidney, urine, bulbourethral gland, skin, and connective tissues. However, the radioactivities of all tissues and organs showed an abrupt decrease during the first 30 min, and after 3 hr, only the urine, kidney and distal portion of the small intestine had any traces of radioactivity. These autoradiographs provide the first evidence that exogenously administered [^<14>C] NeuNAc is taken up highly by the bulbourethral gland and that there are certain differences in intensity of radioactivity within or among the organs.
日本組織細胞化学会の論文