THE DISTRIBUTION OF RADIOACTIVE CARBON FROM L-[U-^<14>C] TYROSINE IN MICE

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概要

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• Tissue and organ distribution of radioactive carbon from ^<14>C-tyrosine in the mouse was studied by whole-body autoradiography and biochemical analysis. The mice injected intravenously with L-[U-^<14>C]tyrosine were sacrificed at various intervals. Examination of autoradiographs disclosed that the injected ^<14>Ctyrosine was rapidly taken up from the blood by the tissues. The radioactivity in the pancreas was the highest and predominant throughout the intervals after injection in this investigation. The comparative values among radioactivity in the organs estimated by a liquid scintillation counter were approximately consistent with those obtained from the whole-body autoradiographs. Radioactivity is the acid-insoluble fractions was increased with time in all organs examined. High-performance liquid chromatography of the acid-soluble fractions disclosed that the amounts of the radioactive tyrosine and its metabolites and/or their molar ratios were different among the organs.

• 日本組織細胞化学会の論文

著者

• Kihara Takashi

  Department Of Cardiovascular Medicine

• Kihara T

  Osaka Medical Coll. Takatsuki Jpn

• Kihara T

  Department Of Anatomy Osaka Medical College

• GOTO Hideyuki

  Department of Bone and Orthopaedics, Nagoya City University Graduate School of Medical Sciences

• Kihara Takashi

  2nd Department Of Anatomy Osaka Medical College

• Kihara Takashi

  Department Of Anatomy Osaka Medical College

• MATSUSHIMA MASAAKI

  Department of Anatomy, Osaka Medical College

• KANAYAMA TADASHI

  Department of Anatomy, Osaka Medical College

• Goto Hideyuki

  Department Of Anatomy Osaka Medical College

• Matsushima Masaaki

  Department Of Anatomy Osaka Medical College

• Goto H

  Osaka Medical Coll. Osaka

• Kanayama Tadashi

  Department Of Anatomy Osaka Medical College

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