Repeated Sauna Therapy Increases Arterial Endothelial Nitric Oxide Synthase Expression and Nitric Oxide Production in Cardiomyopathic Hamsters
スポンサーリンク
概要
- 論文の詳細を見る
Background Vascular endothelial dysfunction is involved in the pathophysiology of chronic heart failure (CHF). It has been reported that sauna therapy, which allows thermal vasodilation, improves vascular endothelial dysfunction in patients with CHF. The present study investigates the mechanisms through which sauna therapy improves endothelial dysfunction induced by CHF. Methods and Results Normal control and male TO-2 cardiomyopathic hamsters were used. Thirty-week-old TO-2 hamsters were treated daily with an experimental far infrared-ray dry sauna system for 15 min at 39℃ followed by 20 min at 30℃. This procedure raised the rectal temperatures by about 1℃. Arterial endothelial nitric oxide (NO) synthase (eNOS) mRNA and protein expressions were examined, and serum concentrations of nitrate were measured. The expression of eNOS mRNA in the aortas of normal controls did not change, whereas those of the TO-2 hamsters decreased with age. Four weeks of sauna therapy significantly increased eNOS mRNA expression in the aortas of TO-2 hamsters compared with those that did not undergo sauna therapy. Sauna therapy also upregulated aortic eNOS protein expression. Serum nitrate concentrations of the TO-2 hamsters were increased by 4 weeks of sauna therapy compared with those that did not undergo sauna. Conclusion Repeated sauna therapy increases eNOS expression and NO production in cardiomyopathic hamsters with heart failure.
- 社団法人日本循環器学会の論文
- 2005-05-20
著者
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Orihara Koji
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagos
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Hamasaki Shuichi
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagos
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Tei Chuwa
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagos
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YOSHIFUKU Shiro
Department of Cardiovascular, Respiratory & Metabolic Medicine, Graduate School of Medicine, Kagoshi
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MIYATA Masaaki
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagos
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ETO Hideyuki
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagos
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Kudoh T
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
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Hamasaki Shuichi
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
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Kihara Takashi
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
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Yoshifuku Shiro
Department Of Cardiovascular Respiratory & Metabolic Medicine Graduate School Of Medicine Kagosh
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IKEDA Yoshiyuki
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagos
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Minagoe Shinichi
Department Of Cardiology National Hosptal Organization Kagoshima Medical Center
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Minagoe Shinichi
Division Of Cardiology National Hospital Organization Kagoshima Medical Center
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Kihara Takashi
Department Of Cardiovascular Medicine
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Orihara Koji
Department Of Cardiovascular Respiratory & Metabolic Medicine Graduate School Of Medicine Kagosh
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Otsuji Yutaka
Department of Cardiology, Kagoshima University
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Biro Sadatoshi
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagos
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Kamogawa Yasuyuki
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagos
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Yu Bo
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagos
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Eto Hideyuki
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
-
Tei Chuwa
Department Of Cardiology Kagoshima University
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Otsuji Yutaka
Department Of Internal Medicine School Of Medicine University Of Occupational And Environmental Heal
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Miyata Masaaki
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
-
Biro Sadatoshi
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
-
Kihara Takashi
Department Of Anatomy Osaka Medical College
-
Yu Bo
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
-
Saitou Yoshihiko
The First Department Of Internal Medicine Nara Medical School
-
Bo Yu
The First Division Of Cardiology National Hospital Organization Kagoshima Medical Center
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Ikeda Yoshiyuki
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
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Saitou Yoshihiko
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
-
Kamogawa Yasuyuki
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
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Etoh Hideyuki
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
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Otsuji Yutaka
Department Of Cardiology And Nephrology University Of Occupational & Environmental Health
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Miyata Masaak
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
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Minagoe Shinichi
Department Of Cardiology National Hospital Organization Kagoshima Medical Center
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Miyata Masaaki
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
-
Miyata Masaaki
Department Of Cardiovascular Respiratory And Metabolic Medicine Field Of Cardiovascular And Respiratory Disorders Kagoshima University Graduate School Of Medical And Dental Sciences
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Miyata Masaaki
Department of Cardiology, Respiratory and Metabolic Medicine, Kagoshima University
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