Acute and Chronic Effects of Smoking on Arterial Stiffness
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概要
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Background: The brachial-ankle pulse wave velocity (baPWV) and cardio-ankle vascular index (CAVI) are used to evaluate arterial distensibility. The purpose of this study was to elucidate the acute and chronic effects of smoking on arterial stiffness as measured by baPWV and CAVI. Methods and Results: Ten male smokers were studied to evaluate the acute effect of smoking on arterial stiffness. To elucidate the chronic effect of smoking on arterial stiffness, 160 male active smokers were analyzed. CAVI and baPWV were calculated by measuring the pulse volume record, blood pressure (BP), and vascular length from heart to ankle. CAVI and baPWV were measured using a VaSera VS-1000. In the acute study, baPWV and CAVI increased immediately after smoking 1 cigarette. In the chronic study, baPWV and CAVI significantly correlated with mean BP (MBP) and the Brinkman index. In multiple regression analysis, baPWV independently correlated with MBP, and CAVI independently correlated with the Brinkman index, but not with MBP. Receiver-operating characteristics (ROC) curves of baPWV and CAVI to predict Brinkman index ≥500 demonstrated that the area under the ROC curve of CAVI was higher than that of baPWV. Conclusions: Smoking causes a significant increase in arterial stiffness as measured by baPWV and CAVI. CAVI correlated with the Brinkman index, which suggests that CAVI is a useful index of the degree of arterial stiffness caused by smoking. (Circ J 2011; 75: 698-702)
- 2011-02-25
著者
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Hamasaki Shuichi
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagos
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Tei Chuwa
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagos
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MIYATA Masaaki
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagos
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KUBOZONO Takuro
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagos
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UEYAMA Kiyo
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagos
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KUSANO Ken
JA Kagoshima Kouseiren Medical Health Care Center
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KUBOZONO Osamu
JA Kagoshima Kouseiren Medical Health Care Center
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Hamasaki Shuichi
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
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Hamasaki Shuichi
The 3st Department Of Internal Medicine Faculty Of Medicine Kagoshima University
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Tei C
First Department Of Internal Medicine Kagoshima University Graduate School Of Medical And Dental Sci
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Tei Chuwa
鹿児島大学 医歯学総合研究科循環器・呼吸器・代謝内科学
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Tei Chuwa
Department Of Cardiology Kagoshima University
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Miyata Masaaki
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
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Tei Chuwa
Division Of Cardiac Repair And Regeneration Graduate School Of Medical And Dental Sciences Kagoshima
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Kubo Tadahiro
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
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Tei Chuwa
First Department Of Internal Medicine Kagoshima University
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Maeda Masato
The 1st Dept. Of Internal Medicine Kagoshima University
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Miyata Masaak
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
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Ueyama Kiyo
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
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Miyata Masaaki
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
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Tei Chuwa
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
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Tei Chuwa
Department Of Cardiovascular Medicine Kagoshima University
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Hamasaki Shuichi
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
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Kubozono Takuro
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
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Tei Chuwa
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
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Miyata Masaaki
Department Of Cardiovascular Respiratory And Metabolic Medicine Field Of Cardiovascular And Respiratory Disorders Kagoshima University Graduate School Of Medical And Dental Sciences
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Miyata Masaaki
Department of Cardiology, Respiratory and Metabolic Medicine, Kagoshima University
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