ALTERATIONS OF LOCAL CEREBRAL BLOOD FLOW DURING HYPOXIC HYPOXIA : ^<14>C-IODOANTIPYRINE AUTORADIOGRAPHIC STUDY

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概要

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• The effects of hypoxic hypoxia on local cerebral blood flow was studied by using ^<14>C-iodoantipyrine autoradiography. Hypoxia (8%O_2 and 6%O_2 for 30 min) was induced in mice without control of the temperature and blood pressure. Percent decreases in cerebral oxygen tension (P cortex O_2) during 8%O_2 and 6%O_2 hypoxia were 80% and 92%, respectively. Under normal conditions (21%O_2), P cortex O_2 was 17.4±4.0 mmHg. Optical density (OD), main factors responsible for the measurement of local cerebral blood flow were observed by the scanning micro-densitometer. The pyramidal cell layer of the hippocampus, choroid plexus, and venous (sinus) blood did not decrease in ODs during hypoxic hypoxia, while ODs in all other cerebral regions examined significantly decreased as compared with that of the control (P<0.01). In others, amygdala showed a marked decrease (ca. 30%) in ODs during hypoxic hypoxia.

• 日本組織細胞化学会の論文

著者

• OZAKI Hiroki

  Department of Oral Pathology Kagoshima University Dental School

• SHIMONO RYOICHI

  Department of Anatomy, Osaka Medical College

• MURAKAMI Tetuhide

  Department of Biology and Physiology, Kagawa Medical School

• Ozaki Hiroki

  Department Of Biology Toyama Medical And Pharmaceutical University

• SHIMADA Masahisa

  Departments of Anatomy, Osaka Medical College

• Shimada M

  Department Of Anatomy Osaka Medical College

• Shimada Masahisa

  Department Of Anatomy Kagawa Medical School

• IMAHAYASHI TOMIO

  Department of Anatomy Kagawa Medical School

• Shimono Ryoichi

  Department Of Anatomy Osaka Medical College

• Shimono Ryoichi

  Department Of Anatomy Kagawa Medical School

• Murakami Tetuhide

  Departments Of Biology Kagawa Medical University

• Murakami T

  Department Of Biology Faculty Of Medicine Kagawa Medical University

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