Immunohistochemical Analysis of Lipoprotein (a) Deposition and Inflammatory Cells in Coronary Atherosclerosis

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概要

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• The depostion of lipoprotein (a) (Lp(a)) of coronary sclerosis was immunohistochemically studied by using 9 autopsy cases and compared with the infiltration of the inflam-matory cells such as macrophages (Mp), T-lymphocytes (T-cells) and B-lymphocytes. Lp (a) deposition was recognized in 6 cases out of 9. The type of atherosclerosis was classified according to the classification of the American Heart Association. In the initial lesions, type l, Lp (a) was deposited unevenly in the subintimal region and the infiltration of Mp was recognized without lymphocytes. In the advanced lesion, type III, Lp (a) was deposited primarily among extracellular tissues. In the more advancedlesion, type IV, Lp(a) was identified withinMp as well. In the shoulder region of theadvanced lesion, the Lp(a) deposition and theinfiltration of Mp and T-cells were recognizedto colocalize in the limited zone withoutsmooth muscle cells. This finding suggested this limited zone would be vulnerable to stress and induce the following rupture of the lipid cor. In addition, Lp (a) was deposited and formed double layers in the advanced sclerotic fibrous lesion. Thesepathological findings suggested the importance of Lp (a) in atherosclerosis and the subsequent rupture of the advanced lesion in relation to inflammatory cells.

• 日本組織細胞化学会の論文

著者

• ISHIKAWA Yuichi

  Faculty of Health Sciences, Kobe University School of Medicine

• Ishikawa Y

  Faculty Of Health Sciences Kobe University School Of Medicine

• Inatome Tetsuya

  Miki Municipal Hospital

• Inatome Tetsuya

  Miki City Hospital Department Of Cardiology

• Inatome Tetsuya

  Miki City Hospital

• Inatome Tetsuya

  神戸大学 保健

• Watanabe Makoto

  Faculty of Health Science, Kobe University School of Medicine

• Fujiki Hisano

  Miki City Hospital

• Hosokawa Yoshimi

  Miki City Hospital

• Wakabayashi Miyuki

  Miki City Hospital

• Takahashi Akihiro

  Department of Internal Medicine, Kobe University School of Medicine

• Taniguchi Takahiro

  Department of Internal Medicine, Kobe University School of Medicine

• Fujioka Yoshino

  Department of Internal Medicine, Kobe University School of Medicine

• Hosokawa Yohei

  Department Of Pathology Kyoto Prefectural University Of Medicine

• Fujioka Yoshio

  First Department Of Internal Medicine Kobe University School Of Medicine

• Takahashi Akihiro

  Division Of Clinical Preventive Medicine Department Of Community Preventive Medicine Niigata Univers

• Watanabe M

  Department Of Anatomy Osaka Medical College

• Ishikawa Yuichi

  Faculty Of Health Science Kobe University School Of Medicine

• Ishikawa Yuichi

  Faculty Of Bioresource Sciences Akita Prefectural University

• HOSOKAWA Youhei

  Dept. Path. Kyoto Pref. Univ. Med.

• Ishikawa Y

  Univ. Ryukyus Okinawa Jpn

• Fujioka Yoshio

  Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University

• Taniguchi Takahiro

  Division Of Cardiovascular And Respiratory Medicine Kobe University Graduate School Of Medicine

• Takahashi Akihiro

  Department Of Chemistry Faculty Of Fisheries Hokkaido University

• Watanabe Makoto

  Faculty Of Engineering Chiba University

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