The Relation of 5'flanking Region of the Apolipoprotein(a) Gene to Serum Lipoprotein(a) Level
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概要
- 論文の詳細を見る
Lipoprotein(a) (Lp(a)) is an atherogenic lipoprotein whose serum concentration is considered to be mainly determined by apolipoprotein(a) (apo(a)) size and its production rate. Three types, of variation have been identified in the apo (a) gene; a size polymorphism in the coding region, a pentanucleotide repeat polymorphism. In the promoter region, and sequence variation in coding and non-coding regions of the gene including a C/T polymorphism at +93 from the transcription start. To clarify if the analysis of these polymorphisms could predict the serum levels of Lp(a), we subcloned the 1.4 kb 5'flanking region of apo(a) gene from subjects with low (≦10 mg/dl, n=2) and high (> 100 mg/dl, n=3) serum levels of Lp(a) and compared the promoter activity by in vitro transcription assay with HepG2 cells and furthermore studied the response of interleukin-6 and estradiol which had been reported to alter serum levels of Lp(a). Every subject in our study showed C at +93. The basal promoter activity of high Lp(a) group was not higher than that of low Lp(a) group. We did not find that. A size polymorphism and pentanucleotide repeat polymorphism in this region affected the promoter activity. Interleukin-6 had a tendency to enhance the promoter activity, but estradiol did not. In conclusion, serum level of Lp(a) in individual was not predicted by the analysis of polymorphisms of 1.4 kb 5'flanking region of apo(a) gene. There may be other factors. That are responsible for the regulation of the concentration of serum levels of Lp(a).
- 神戸大学の論文
- 2001-11-30
著者
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Yokoyama Mitsuhiro
Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University
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Shimizu Hiroshi
The First Department of Internal Medicine, Kobe University School of Medicine
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Taniguchi Takahiro
The First Department of Internal Medicine, Kobe University School of Medicine
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Fujioka Yoshio
The Department of Internal Medicine, Cardiovascular Division, Hyogo College of Medicine
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Takahashi Akihiro
The First Department of Internal Medicine, Kobe University School of Medicine
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Ishikawa Yuichi
The Faculty of Health Sciences, Kobe University School of Medicine
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Yokoyama Mitsuhiro
The First Department of Internal Medicine, Kobe University School of Medicine
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Ishikawa Y
Faculty Of Health Sciences Kobe University School Of Medicine
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Fujioka Yoshio
The Department Of Internal Medicine Cardiovascular Division Hyogo College Of Medicine
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Fujioka Yoshio
First Department Of Internal Medicine Kobe University School Of Medicine
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Takahashi Akihiro
Division Of Clinical Preventive Medicine Department Of Community Preventive Medicine Niigata Univers
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Ishikawa Yuichi
Faculty Of Health Science Kobe University School Of Medicine
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Ishikawa Y
Univ. Ryukyus Okinawa Jpn
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Yokoyama Mitsuhiro
The First Department Of In Internal Medicine Kobe University School Of Medicine
-
Fujioka Yoshio
Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University
-
Taniguchi Takahiro
Division Of Cardiovascular And Respiratory Medicine Kobe University Graduate School Of Medicine
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Shimizu Hiroshi
The First Department Of Internal Medicine Kobe University School Of Medicine
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