Dynamic Effects of Intravenous Procainamide Infusion on the Electrophysiological Properties During Atrial Fibrillation
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概要
- 論文の詳細を見る
Although the mechanism of atrial fibrillation(AF) is still controversial, multiple wandering reentry is considered the primary mechanism in most AF. It has been suggested that prolongation of the wavelength would make it impossible for the reentry to continue and would lead to the termination of the AF. In the present study a dynamic fluctuation in the electrophysiological properties was observed with procainamide infusion during AF. In 12 patients, both the local electrogram and mopnohasic action potentials(MAP) during AF were recorded from the right atrium before, during and after infusion of procainamide(10mg/kg). The minimum AF cyclelength(CLmin), MAP duration at 90% repolarization(MAPD90) and widths of the intraatrial potentials(WAP) were measured with custom-made computer software. The conduction velocity index(CVI) was determined from the WAP. The wavelength index(WLI=CVI×CLmin) and postrepolarization refractoriness(PRR=CLmin-MAPD90) were calculated. In 6 patients, AF was terminated by procainamide infusion(group A), but not in the other 6 patients(group B). Group A patients showed a biphasic change in the parameters following procainamide infusion. In phase I, the CLmin, MAPD90 and PRR increased, while the CVI decreased, and the WLI remained unchanged. In phase II, the PRR, CVI and WLI increased and the AF was terminated. No restoration of the CVI nor increase in the WLI were observed in group B. The biphasic fluctuation in the CVI and the remarkable increase of the PRR and WLI were observed before termination of AF by procainamide infusion.
- 社団法人日本循環器学会の論文
- 1998-12-20
著者
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Yokoyama Mitsuhiro
()
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Yokoyama Mitsuhiro
富山大学 医学部バイオ統計学臨床疫学
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Yokoyama Mitsuhiro
Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University
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Yokoyama Mitsuhiro
The First Department of Internal Medicine, Kobe University School of Medicine
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Inoh Tsutomu
Kobe University School Of Medicine First Department Of Internal Medicine
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Inoue Tomoo
First Department Of Internal Medicine Kobe University School Of Medicine
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INOUE TOMOO
The First Department of Internal Medicine, Kobe University, School of Medicine
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OHNISHI YOSHIO
The First Department of Internal Medicine, Kobe University, School of Medicine
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Ohnishi Yoshio
First Department of Internal Medicine Kobe University School of Medicine
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Shima Takashi
The First Department of Internal Medicine, Kobe University School of Medicine
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Shima takashi
First Department of Internal Medicine, Kobe University School of Medicine
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Ohnishi Yoshio
The First Department Of Internal Medicine Kobe University School Of Medicine
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Ohnishi Yoshio
Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University
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Inoh Tsutomu
Department Of Internal Medicine Devision I Kobe University School Of Medicine
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Shima Takashi
First Department Of Internal Medicine Kobe University School Of Medicine
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Inoue Tomoo
From The First Department Of Internal Medicine Kobe University School Of Medicine
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Yokoyama Mitsuhiro
The First Department Of In Internal Medicine Kobe University School Of Medicine
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Inoue Tomoo
The First Department Of Internal Medicine
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Inoue Tomoo
First Department Of Internal Medicine. Kobe University School Of Medicine
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Ohnishi Yoshio
Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University
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