The Plasma Levels of Leptin were Correlated with the Metabolic Cardiovascular Risk Factors such as Obesity and Dyslipidemias in Healthy Subjects

概要

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Leptin, the gene product of the ob gene, may play an important role in regulating body weight by signalling the size of the adipose tissue mass. It has been reported that the plasma levels of leptin were correlated with the body mass index (BMI). The obesity is associated to the insulin resisitant state. So we investigated the relation between the plasma leptin levels and the plasma levels of glucose and lipids such as cholesterol, triacylglycerol (TG) and high density lipoprotein cholesterol in healthy subjects. The plasma levels of leptin in female were significantly higher than that in male. The plasma levels of leptin were well correlated with BMI in both male and female. The plasma glucose levels in female correlated with the plasma leptin levels, but not in male. The plasma levels of cholesterol in both male and female were not correlated with the plasma leptin levels. The plasma TG levels in female correlated with the plasma leptin levels, but not in male. We also measured the plasma levels of tumor necrosis factor-alpha, but there was no correlation with the plasma leptin levels. The plasma leptin level may reflect the adipose tissue mass and might relate with coronary risk factors.
神戸大学の論文
1999-12-26