Lectin histochemical studies on renal tumors.
スポンサーリンク
概要
- 論文の詳細を見る
Histochemical characteristics on lectin binding of 16 cases of nephroblastoma and of 57 cases of renal cell carcinoma were studied on those of six embryonal and fetal kidneys in 4 to 24 gestational weeks and in six normal adult kidneys using four biotinylated lectins (PNA, LTA, SBA and UEA-1), which show segment specific binding for normal nephron. In normal nephrogenesis, Gal beta 1-3 GalNAc (PNA receptor) appeared at first in developing tubuli of the metanephros at 10 gestational weeks, and remained positive in proximal tubuli of 13 gestational weeks, where the Lewis X antigen (LTA receptor) emerged. In adult kidneys, Gal beta 1-3 GalNAc distributed along distal tubuli and collecting ducts and not in proximal tubuli. Type 2 H antigen (UEA-1 receptor) was confined to collecting ducts. In nephroblastomas, positive reaction to these lectins were almost exclusively confined to tubular structures. Gal beta 1-3 GalNAc was constantly positive there. Intensely positive stain of Lewis X antigen was observed in three cases of histologically well differentiated type. Lewis X antigen positive tubuli co-expressed Gal beta 1-3 GalNAc. There were six type 2 H antigen positive cases showing differentiation toward ureteric bud or collecting ducts. In view of the cell surface glycosylation, regular differentiation of fetal renal tubuli was also retained in nephroblastomas according to their degree of histological differentiation. In renal cell carcinoma, Gal beta 1-3 GalNAc was positive in 49% (28/57) and Lewis X antigen was positive in 54% (31/57). Type 2 H antigen was completely negative. In contrast to the nephroblastoma, there was no correlation between histological features and lectin binding patterns in renal cell carcinoma.
- 神戸大学の論文
著者
-
Ito H
Department Of Chemistry Faculty Of Science And Engineering Aoyama Gakuin University
-
Imai Y
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
-
Hanioka K
Department Of Pathology Kobe University School Of Medicine
-
Watanabe M
Department Of Agricultural And Biological Chemistry College Of Bioresource Sciences Nihon University
-
Ito H
Department Of Cardiovascular Medicine Akita University Graduate School Of Medicine
-
Hanioka K
Department of Pathology, Kobe University School of Medicine
関連論文
- Perfect Control of Diastereomeric Complexation of C_2 - Symmetric Chiral 1, 1' - Bis(oxazolinyl) ferrocene Ligands
- Multifocal Fibrosclerosis as a Possible Cause of Panhypopituitarism with Central Diabetes Insipidus
- A case of acute encephalitis with refractory, repetitive partial seizures, presenting autoantibody to glutamate receptor Gluε2
- Successful Management of Intractable Epilepsy with Lidocaine Tapes and Continuous Subcutaneous Lidocaine Infusion
- Refiection Measurements of RbI Films in the Ultraviolet
- Differential Inhibition of Calpain and Proteasone Activities by Peptidyl Aldehydes of Di-Leucine and Tri-Leucine
- A Direct and Selective Syntheses of α, α-Dichloro-and α-Chloro-ethyl Ketones by the Reaction of Alkyl Carboxylates with 1, 1-Dichloroethyllithium
- SUCCESSFUL CLINICAL APPLICATION OF TISSUE ENGINEERED BLOOD VESSEL
- An Effective Method for the Preparation of Chiral Polyoxy 8-Membered Ring Enone Corresponding to the B Ring of Taxol
- An Effective Method for the Preparation of Optically Active Polyoxy 8-Membered Ring Enone Corresponding to the B Ring of Taxol
- HIV-1 Reverse Transcriptase-Inhibitory Compound in Salvia officinalis
- Interphase cytogenetic and AgNOR analyses of hydatidiform moles
- 39 SIBLING CASES OF HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA
- Direct and Selective Syntheses of α, α-Dichloroethyl Ketones or Their Ethyl Trimethylsilyl Mixed Acetals by the Reactions of Methoxymethyl or Etyhyl Carboxylates with 1, 1-Dichloroethyllithium in the Presence of Chlorotrimethylsilane
- Morphological studies on the placenta.
- Lectin histochemical studies on renal tumors.
- Clinical investigation of the relationship between Borna disease virus (BDV) infection and schizophrenia in 67 patients in Japan.
- Upper Motor Neuron Syndrome in a patient with Marked Frontal Lobe Atrophy
- Histopathological studies on senile plaques in brains of patients with Down's syndrome.
- Pathological studies on the placenta from pre-term and term maternal toxicosis.
- Infantile neuroaxonal dystrophy--immunohistochemical and ultrastructural studies on the central and peripheral nervous systems in infantile neuroaxonal dystrophy.
- Pathological findings in dicephalus dipus dibrachius: implications for mechanisms in two pairs of lateral conjoined twins.